Alternative Name(s) of Target: hCG; Human chorionic gonadotropin; Choriogonadotropin subunit beta Immunogen: Human chorionic gonadotropin.

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Antibody first published in: de Haard HJ, Kazemier B, van der Bent A, Oudshoorn P, Boender P, van Gemen B, Arends JW, Hoogenboom HR. Absolute conservation of residue 6 of immunoglobulin heavy chain variable regions of class IIA is required for correct folding. Protein Eng. 1998 Dec;11(12):1267-76. PMID:9930677 Note on publication: Describes the generation of scFvs from murine monoclonal antibodies, and the effect of several amino acid mutations on the immunoglobulin fold and antigen binding affinity.

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Recombinant monoclonal antibody to Human Chorionic Gonadotropin. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma AB4.

Application Notes: The antibody binds specifically to hCG, a hormone produced by a part of the placenta, the syncytiotrophoblast, following implantation. The hormone has an important role during pregnancy, as it interacts with the LHCG receptor in the ovaries to prevent the degeneration of the corpus luteum, and thereby allows the secretion of progesterone during the first trimester. hCG is a heterodimeric glycoprotein, composed of an α and a β domain, of which the α is identical to that of LH and FSH, while the β is unique to hCG. The monoclonal antibody AB4 is specific for the β-subunit, and can be used in the detection of the hormone in pregnancy tests or in the diagnosis of uterine cancer.