Dec 16, 2021 — Long Focal Length Telescopes for Astrophotography · EdgeHD telescope Long-focal-length scopes are ideal for imaging the Moon, planets, and the ...

Multiview browser for YouTube

Skeletal editing could help to speed up drug discovery dramatically, and chemists such as Julia Reisenbauer, a PhD student working in Prof Bill Morandi’s team at the Swiss Federal Institute of Technology, and Prof Sarah Wengryniuk at Temple University in Philadelphia, have now developed reactions that can insert single nitrogen and oxygen atoms into the central rings of some molecules, sidestepping the need to start from scratch.

Scientists usually make new drugs by identifying a biological target that plays some role in a disease, and then screening hundreds of thousands of molecules to find a “hit” compound that might interact with it. “Making molecules for a drug discovery project requires many chemical steps and significant time,” Dr David Blakemore, head of synthesis, inflammation, immunology and anti-infectives chemistry at Pfizer, acknowledges.

With the planet already choking on a surfeit of plastic, however, a method for making more of it isn’t necessarily appealing. Human negligence aside, plastics are notoriously difficult to recycle because of the long chains of strongly bonded atoms that make up their backbones. These bonds can sometimes be broken with extreme heat, but the process is hardly sustainable. “Even if it does work, it requires a high input of energy,” says Zhukhovitskiy.

In recent decades, this has increasingly been done with computers, and so-called in silico screening is now so advanced that synthetic chemistry sometimes struggles to keep up.

“We’ve gotten to the point in synthetic chemistry where people genuinely believe that most molecules are conquerable with enough time and effort,” he says. “But there are a couple of notable exceptions. I think that if we could demonstrate that we can make some of those with skeletal editing, that’d be awesome.”

“It’s like tearing down your house and rebuilding it just to remodel one bathroom,” Levin says. “Everything in these sorts of applications is about speed, and when you’re dealing with drugs, you’re talking about patients who are waiting for a cure or a better treatment.”

Instead, in this new approach they harness chemical reagents, catalysts or light, to perform edits quintillions of times. “What we’re essentially doing is designing molecules that behave like that tweezer,” Levin explains.

To make a new synthetic material, chemists will often take monomers – small molecules that can be bonded together – and repeat them many times to form polymers. This traditional approach limits their designs to using only available monomers, which can be difficult to access, or unsustainable.

Still, a number of these reactions can only produce small amounts of product, many use volatile reagents that could be useful in drug discovery but inappropriate for industrial use, and while some reactions may be more environmentally sustainable than available methods, others could be worse. Critics could also argue that this 5% represents low-hanging fruit, and the remaining 95% may be considerably more difficult, if not impossible.

by S Kim · 2018 · Cited by 146 — We have developed a low-cost OCT system which cost $7,200 for the components which include a PC, light source, customized spectrometer, and 3D ...

⑧ Exit to Full Screen :  Save your favorite Multi View configuration via the Save/Exit pop-up. This will create a saved card, through which you can immediately enter your favorite configuration the next time you use Multi View.

Petersburg Skin and Laser center. Skin Conditions ... heat and leaving the surrounding skin untouched. ... Can I use makeup to cover the treated area after my red ...

Levin won’t say what they are, but his team has two such exceptions in its sights. Can skeletal editing bring a molecule into existence that we could only imagine before?

• Sports : Enjoy watching your favorite sports games together or multi-talk by connecting your mobile.         • Home Workout : Try exercising while watching content. To watch yourself during the workout, choose a layout with your mobile or camera.

Step 1. On your Samsung remote, press the Home button.     Step 2. Click Apps 〉 Search.     Step 3. Search for apps you want.     Step 4. Click Download.

Once they have succeeded in piecing together a molecule they want to work with, medicinal chemists must then optimise it to improve efficacy and reduce side-effects – turning the “hit” compound into a “lead” compound.

Multi viewsfree

Multi view enriches your watching experience by providing multi-content for each lifestyle or interest. Please follow the instructions below to start Multi View.

Zhukhovitskiy’s team is close to completing a government-funded project to use skeletal editing for recycling rubber, and there’s growing interest in these techniques within industry, especially in pharmaceuticals.

For Levin, these possibilities lead back to the pure fascination with manipulating matter, making things that otherwise might never have existed.

The Ophir Orion is a microprocessor-based Laser. Power/Energy Meter for measuring laser power or energy with Ophir measuring heads. It uses smart connector.

We may never get to that stage, but each new skeletal editing reaction could open the door to more and better medicines, new materials, better crop protections, and solutions to a range of other problems. Sarpong, however, thinks these are “rather myopic predictions”.

To use MultiView, a USB camera can be supported. For more details on USB cameras, please visit How to Google Duo on Samsung TV.

With enough effort, today’s chemists can synthesise almost any molecule imaginable, but their methods are limited, relying on the molecular building blocks available and potentially requiring many steps. “The approach that has been adopted to do this is to add other chemical groups to the already existing molecule, which changes it only on its periphery,” explains Prof Richmond Sarpong, a chemist at the University of California, Berkeley.

In that sense, skeletal editing is a continuation of established synthetic chemistry – not so much a single tool as an ever-growing toolbox. “[It is] not one thing,” says Sarpong. “It is a concept, a way of thinking, that has sparked a new way to look at things and is producing results that I could not have imagined five years ago.”

• HDMI sources (STB/Console/OTT box/BDP/Laptop etc)      • Tuner      • Mobile mirroring (Android/iOS)      • Laptop mirroring (iOS/Windows10↑)      • YouTube Casting      • USB camera      • SmartThings camera      • Ambient(Clock/Weather)

“A different approach would be where you have a problem and you design a polymer without those constraints, you just design,” says Aleksandr Zhukhovitskiy, assistant professor of chemistry at the University of North Carolina at Chapel Hill. “[Skeletal] editing will allow you to derive that material from something else that then could be accessed more easily or perhaps accessed through more sustainable building blocks.”

He’s joined by a growing number of labs globally whose efforts are fast increasing the pace of discovery. “If the toolbox that I’m imagining actually comes to fruition,” he says, “it will really replace a lot of the ways that we do chemistry.”

100MultiView Browser

⑥ Set Sound Output : Connect your Bluetooth headphone to the screen and listen to the audio separately. Works for watching video clips while a family member is watching a TV show.

Some of those things that would never have existed are of immense value to humanity. From synthetic dyes to celluloid, materials to medicines, synthetic chemistry has made our world a richer place, and helped us live longer to enjoy it.

ViewSync

This article was amended on 5 August 2023. Due to a typesetting error, the number 1023 was incorrectly rendered in an earlier version as 1,023.

When it comes to altering an existing molecule more fundamentally – such as within the rings of carbon atoms at the centre of many organic compounds – Levin likens those atoms and bonds to the connectors and rods in a child’s Tinkertoy set: “It’s very obvious when you’re looking at the toy that the best way to change it would be to pull out the part you don’t want and put the new one in,” he says. “It has always bothered me that that’s not something we have the capacity to do chemically.”

Blakemore says it is “still early days”, adding that their project demonstrates the “potential power” of skeletal editing. Indeed, it was only in 2018 that Sarpong’s group became one of the first to start working with these reactions, with most advances happening in the last two years, but progress has been fast. Levin estimates that a complete skeletal editing toolbox for drug discovery would involve maybe a thousand different reactions, and is now about 5% full. “But you have to remember, it’s been two years,” he says, “5% is not bad, you know; 5% is pretty good, actually.”

This site uses cookies to personalise your experience, analyze site traffic and keep track of items stored in your shopping basket. By Clicking ACCEPT or continuing to browse the site you are agreeing to our use of cookies. See our Privacy Policy here

by L Pezze · 2007 · Cited by 383 — Abstract page for arXiv paper 0705.4631: Mach-Zehnder Interferometry at the Heisenberg Limit with coherent and squeezed-vacuum light.

Multiview website

“Currently, we are examining the available skeletal editing methodology to see how applicable it is across a broad range of molecules to help us understand scope and limitations,” says Blakemore at Pfizer. “We already have a project where we have used a skeletal editing reaction to make a simple scaffold that was elaborated to a lead compound.”

You can change the focus of each screen using your remote. The Contextual Menu appears once you press the Select button with your remote on the focused screen.

② Enter Content Selection Mode : You can browse and select content within the Content Selection Mode. Press and hold the Return button on the remote to return to the Multi View mode.  You can also press and hold the Select button on the remote to enter the Content Selection Mode.

Shop Sight Level, 1x Magnification, Optical Level at MSC Direct top provider of high quality products.

Das beste Makro-Objektiv für dich! Was willst du fotografieren? Keine Ahnung? Dann wird es schwer. Für statische Motive reicht meist ein Makro-Objektiv mit ...

Ask Mark Levin what excites him about his work, and the associate professor of chemistry at the University of Chicago could double as a poet. “We’re one of the only fields of science that at its core is about making things that have never existed anywhere else in the universe, and would never have existed if we didn’t intervene,” he enthuses. “We get to manipulate matter at the atomic level to shape it to whatever purpose we can think of.”

“I can design a molecule that looks sensible or follows all the rules of chemistry,” says Dr Robert Scoffin, CEO of Cambridge-based drug discovery company Cresset, “and the synthetic guys will look at it and go: ‘I’m sorry, I really can’t get there, or it’s going to cost you so much it’s really not worth getting there.’”

This can be laborious. For example, chemists will often test versions of a molecule with a nitrogen atom occupying every possible position in its structure, and while editing atoms on a molecule’s periphery can be relatively straightforward, changing those at its core can be as tricky as the last round in a game of Jenga.

A full skeletal editing toolbox could do more than that. It could in theory lead to futuristic inventions such as automated synthesis laboratories, and even personalised medicine.

K Polak · 3 — 3D POLARISATION OF A STRUCTURED LASER BEAM AND PROSPECTS. FOR ITS APPLICATION TO CHARGED PARTICLE ACCELERATION. K. Polak1, J.-C. Gayde, CERN, Geneva ...

④ Set Picture-in-Picture : You can choose which corner you want to position the PIP screen and you can change the background and foreground screen as well.

Multi viewsyoutube

A new method called ‘skeletal editing’ offers a hugely simplified way to alter matter, paving the way for world-changing innovations in personalised medicine and sustainable plastics

Emapp YouTubeMultiView

Scoffin suggests that in cancer treatment, for instance, where every tumour is different: “You can imagine a world where you can design exactly the right molecule to go and attack that specific tumour, and you have a synthesiser where you can draw that molecule, click a button and it makes it. That opens up a huge world of possibility in terms of that kind of personalised precision medicine.”

Inspired in part by the revolutionary genome-editing technology Crispr-Cas9, Levin and Sarpong are among a handful of chemists developing new methods to insert, delete and swap individual atoms within molecules. They call it “skeletal editing” and they hope it will change their field – and our world.

His group is now working on a skeletal editing reaction that can insert weak links into the backbone of the plastic polyethylene, making it possible to break those tough bonds under relatively mild conditions. “Suddenly your polymer still behaves like polyethylene in many ways, but becomes more easily cleavable,” he says. “That is a really exciting goal, I think, and a really challenging one.”

J Stöhr · 2019 · 35 — Abstract. The nature of light, extending from the optical to the x-ray regime, is reviewed from a diffraction point of view by comparing field-based ...

Samsung.com Services and marketing information, new product and service announcements as well as special offers, events and newsletters.

With the 2021 Multi View feature, you can enjoy your favorite contents - all at once - on your TV, including live channels, apps, gaming consoles and mirrored contents from your mobile devices.

Birefringent polarizers rely on the dependence of the refractive index on the polarization of light. Different polarizations will refract at different angles ...

“I think the most important thing is that it changes the way chemists think,” he says. “Meaning the possibilities are endless.”

• Supported screen mirroring compatible devices included smart phones or tablets. (Android 4.2 and higher)      • Supported airplay 2 compatible devices included iPhone, iPad, iPod touch or Mac book.      • Laptops/PCs with Windows 10

“It is very time consuming to change the central scaffold itself,” explains Blakemore. “We typically need to make a new scaffold from scratch, and this often requires many steps in a long sequence.”

“It will increase the speed at which we can make things, and it will increase the diversity of products we can make,” says Martin Smith, professor of organic chemistry at Oxford University. “That is absolutely part of the discovery process for pharmaceuticals and will be for the discovery process for materials as well.”

Multi viewsemapp

The word “editing” evokes chemists altering atoms with pairs of nanoscopic tweezers, but that would be far from efficient. “If you wanted to make a mole,” Levin explains, referring to a unit of measurement used in chemistry, “you would have to take that pair of tweezers and do it 1023 times.”

⑤ Set Sound Distribution : Select this option to listen to the audio from both screens at once. Works for watching a TV show while referring to a home workout video guide also.

Zhukhovitskiy’s lab has developed a skeletal editing reaction to synthesise vinyl polymers – employed in everything from plexiglass to paints – without the use of vinyl monomers, effectively making a petrochemical plastic without the need for petrochemicals.

To use Multi View on a Samsung TV, there are supported TV models / sources / mobiles / USB cameras and apps. For more details, please read the information below.