Ultrasound will be used to help guide a long, thin, hollow needle through your belly and into the uterus and placenta. This may be slightly painful. You may feel a cramp as the needle enters the uterus.

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Tell your healthcare provider if you are sensitive to or are allergic to any medicines, latex, iodine, tape, and anesthetic medicines (local and general).

Tell your provider if you have a history of bleeding disorders or if you are taking any blood-thinning (anticoagulant) medicines, aspirin, or any other medicines that may affect blood clotting. You may need to stop these medicines before the procedure.

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Uterus (womb). This is a hollow, pear-shaped organ in a woman's lower belly. It sits between the bladder and the rectum. It sheds its lining each month during menstruation. When a fertilized egg (ovum) becomes implanted in the lining, a baby grows.

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Tell your provider if you are Rh negative. During the CVS procedure, blood cells from the mother and baby can mix. This may lead to Rh sensitization and breaking down of the baby’s red blood cells. In most cases, prenatal blood tests will have found out if you are Rh negative. You may be asked to provide these lab results before the procedure.

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There may be other risks depending on your specific health condition. Talk about any concerns with your healthcare provider before the procedure.

If a transabdominal procedure was done, check the bandaged needle site on your belly for any bleeding or leaking of other fluid.

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Cervix. This is the lower part of the uterus that dips down into the vagina. It is made of mostly fibrous tissue and muscle. It has a circular shape.

Chorionic villus sampling (CVS) is a prenatal test. It’s used to test for chromosomal abnormalities and other genetic problems. During the test, a tissue sample is taken from the placenta and sent to a lab for analysis. The placenta is a structure in the uterus that provides blood and nutrients from the mother to the baby.

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You and your baby will be watched for a while after the procedure. Your vital signs and the baby’s heart rate will be checked periodically for an hour or longer.

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For an abdominal CVS, your belly will be cleansed with an antiseptic. You will be instructed not to touch the sterile area on your belly during the procedure.

Based on the location of the placenta, the CVS procedure will be performed through your cervix (transcervical). Or it will be done through your abdominal wall (transabdominal).

Tell your provider about all the medicines that you are taking. This includes prescription and over-the-counter medicines, vitamins, herbs, and other supplements.

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If you are Rh negative, you may be given Rho(D) immune globulin. This is a special blood product that can prevent an Rh negative mother's antibodies from reacting to Rh positive fetal cells.

The healthcare provider may inject a local anesthetic to numb the skin. If a local anesthetic is used, you will feel a needle stick when the anesthetic is injected. This may cause a brief stinging feeling.

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The chorionic villi are tiny projections of placental tissue that look like fingers. They have the same genetic material as the baby. Testing may be done for other genetic defects and disorders. This will depend on the family history, and on the types of lab testing that are available at the time of the procedure.

Amniotic sac. This is a thin-walled sac that surrounds the baby during pregnancy. The sac is filled with amniotic fluid. This is liquid made by the baby. The sac also contains the amnion. This is the membrane that covers the fetal side of the placenta. This protects the baby from injury and helps to control the temperature of the baby.

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CVS is usually done between the 10th and 12th weeks of pregnancy. Unlike amniocentesis (another type of prenatal test), CVS does not provide information on neural tube defects, such as spina bifida. For this reason, women who have CVS also need a follow-up blood test between 16 to 18 weeks of their pregnancy. This is to screen for neural tube defects.

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You will be asked to sign a consent form that gives your healthcare provider permission to do the procedure. Before you sign, read the form carefully. Ask questions if anything isn't clear.

You may or may not be asked to have a full bladder right before the procedure. Depending on the position of the uterus and placenta, a full or empty bladder may help move the uterus into a better position for the procedure.

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You should rest at home. Don’t do any strenuous activities for at least 24 hours. Don't douche or have sex for 2 weeks, or until directed by your healthcare provider.

Chorionic villus sampling may be used for genetic and chromosome testing in the first trimester of pregnancy. Reasons that a woman might choose to have CVS include:

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Another test that may be used to diagnose genetic and chromosomal defects is amniocentesis. This test does give information on neural tube defects.

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Cells will be gently suctioned through the tube into a syringe. You may feel a twinge or slight cramping. More than 1 sample may be needed to get enough tissue for testing.

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The CVS tissue will be sent to a genetics lab for analysis. Counseling with a genetics specialist may be advised depending on the test results.

Placenta. This is a flat organ that only grows during pregnancy. It gives nutrients and other substances from the mother to the baby. The placenta allows the baby to take in oxygen, food, and other substances. It also lets the baby get rid of carbon dioxide and other wastes.

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A CVS procedure may be done on an outpatient basis. This means you go home the same day. Or it may be done as part of a hospital stay. Procedures may vary depending on your condition and your healthcare provider’s practices.

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Umbilical cord. This is a rope-like cord that connects the baby to the placenta. The umbilical cord has two arteries and a vein. They carry oxygen and nutrients to the baby and waste products away from the baby.