Our first goal was to identify the optimal fluence of LED irradiation to reduce the time required for wound closure. There were some variations in the sizes of the initial wounds, due to the difficulty in creating wounds in the flexible skin of the mice. Therefore, the relative wound area was analyzed along with the absolute values. Compared to the baseline values for each group, the wound areas in all groups steadily decreased over time (Fig. 1, 2). The wounds of all groups almost closed on day 15. Therefore, to assess when the effects of irradiation on wound healing appear, the analysis of wound closure at day 3, 5, 10 and 15 was done. When comparing the relative wound area in group A (control) with irradiated groups (group B, C, and D) respectively, more efficient wound closure was observed in group D (40 J/cm2) on day 5 (Table 1). At the same time, there was no significant difference in wound healing between groups A and B (1 J/cm2), C (4 J/cm2) respectively. Additionally, post hoc analysis was done and compared groups to each other. The most efficient fluence on day 5 was 40 J/cm2 (group D), which demonstrated significantly improved wound healing compared to all the groups. After day 5, no significant difference was observed among groups.

Low-level lasers can affect lymphocytes, increasing their proliferation and activation; macrophages, increasing their phagocytosis; and fibroblasts, increasing their growth factor secretion and enhancing the uptake of both fibrin and collagen2. In addition, LLLT increases the motility of epithelial cells and the amount of granulation tissue produced during healing, and may reduce the synthesis of inflammatory mediators3,4, resulting in reductions in skin wound area in both humans and animals. However, the optimal physical variables for LLLT still lack consensus5.

OCTeye test price

Your provider might suggest an optical coherence tomography if you have symptoms that suggest certain eye conditions, or if they see evidence of certain conditions during your eye exam. If you’re at risk of age-related eye problems or other eye diseases, your provider might suggest adding ocular coherence tomography to your regular schedule of eye exams. They can compare the scans over time to observe any changes.

After anesthesia by intraperitoneal injection of tiletamine/zolazepam (Virbac, Seoul, Korea) and xylazine (Bayer, Seoul, Korea) which was necessary to immobilize the mice, four full-thickness wounds were created on the dorsal skin of each mouse using a 8-mm-diameter punch. The wounds were left exposed without sutures or dressings. A total of 40 mice were used to compare the effects of different irradiation fluences on wound healing. The mice were divided randomly into untreated control (group A) and treated groups (n=10 per group). The wounds of the treated groups were irradiated at fluences of 1 J/cm2 (group B), 4 J/cm2 (group C), or 40 J/cm2 (group D) for five consecutive days starting on day 1 when the wounds were made. To determine the optimal duration of treatment, 30 mice (n=10 per group) were treated with 40 J/cm2 infrared light for 5 (IR5), 10 (IR10), or 15 (IR15) consecutive days. A low-intensity LED irradiation device named SHINeY (WON TECH Co., Seoul, Korea) was used as the light source. The intensity was 100 mW/cm2 and the spot size was 4.77 mm×13.15 mm. The distance between the light source and the dorsal skin was approximately 3 cm. Nonirradiated (control) mice were maintained under similar conditions.

There aren’t any risks or side effects associated with an optical coherence tomography. But there are temporary side effects to having your pupils dilated. You’ll be sensitive to light and may have blurry vision for a few hours afterward. Some people get headaches. If you expect to have your pupils dilated, you might want to arrange for someone else to drive you home from the test, since your vision will take time to readjust.

The other goal of our study was to identify the best duration of LED irradiation for wound healing. The effects of 5, 10, and 15 days of radiation (groups IR5, IR10, and IR15, respectively) were compared. Compared to their baseline values, wound areas steadily decreased in all groups (p< 0.001; Fig. 3, 4, and Supplementary Fig. 1). The wound healing was significant at day 5. The wounds of all groups almost closed on day 15. There was no significant difference in wound area reduction between the IR5 and IR10 groups nor between the IR5 and IR15 groups (Table 2). Post hoc analysis revealed no significant difference among the groups.

Full-thickness wounds were created on the dorsal skin using an 8-mm diameter punch, and the wounds were irradiated at 1, 4, or 40 J/cm2 for 5 consecutive days starting on day 1. To determine the optimal irradiation duration, wounds were irradiated at the most potent fluence of previous study for 5, 10, or 15 days. Photographic documentation, skin biopsies, and wound measurements were performed to compare the effects of different treatment parameters.

We have shown that repeated exposure to low levels of light significantly stimulates wound healing in mice and demonstrated more efficient wound closure with certain fluences of 830 nm irradiation.

Dec 2, 2021 — Put simply, a focal length is the measurement of a lens attributed in mm. Often people mistakenly think that this measurement refers to the ...

Fancyes Enhanced Aluminum Front and Rear Axle Set for 1:12 Scale RC Trucks, Argent in Remote- & App-Controlled Toys.

The OCT scanner will scan one eye at a time. You might see a red line while it’s scanning. You won’t feel anything, and nothing will touch your eyes. Try to stay still for the minute or two it takes to scan.

OCTfull form

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

OCTppt

In conclusion, we have shown that repeated exposure to low levels of light significantly stimulates wound healing in mice and demonstrated more efficient wound closure with certain fluences of 830-nm irradiation. Conversely, the duration of irradiation did not significantly affect wound healing. Further studies regarding human wound healing will be required to examine the applicability of these results to clinical LLLT.

An ocular coherence tomography scan takes just a few minutes in your provider’s office. You won’t need to prepare in advance. You might even have one directly after your standard eye exam.

Your provider might want to use eye drops to dilate your pupils before the exam. Then, you’ll sit in front of the scanner and rest your chin on a support attached to it. You’ll focus your eyes on a green target.

The basic biological mechanism behind the effects of LLLT is thought to involve the absorption of red and near-infrared light by mitochondrial chromophores, in particular cytochrome c oxidase (CCO), a component of the mitochondrial respiratory chain15,16,17. CCO activation results in increased production of adenosine triphosphate (ATP), which provides both the energy and phosphate required to regulate a variety of cellular functions. Consistent with this notion, the addition of exogenous ATP stimulated wound healing in an animal model18. Although wound contraction did not increase in mice treated with external ATP, in vitro observations suggest that ATP increases wound contraction by serving as an energy source for motility and contractile force generation, and as a phosphate donor for kinases regulating contraction19,20.

3000 - 11000 nm Quantum-Cascade Laser.

However, after day 5, we observed no statistically significant differences between the groups irradiated with different fluences. The wounds of all groups were almost closed at day 15. We also investigated the effects of treatment duration, and observed no statistically significant differences between the groups. Wound closure begins with an inflammatory phase and re-epithelialization, followed by the remodeling phase, which generally begins 5 to 7 days after injury. In a previous study, while healing curves generated for control mice demonstrated an initial decrease in wound size during days 1 to 4 after injury, the wounds of LLLT-treated mice started to contract immediately after illumination11. Therefore, 5 days of irradiation could be adequate to reduce the wound area.

Wound closure involves the migration of the boundaries of an injury towards its center and can be assessed through related parameters, such as the percentage of wound contraction10. In this study, we investigated the effect of LED irradiation fluence on wound closure and the effect of the duration of LED irradiation on wound closure. Regarding the results of day 5, the most potent fluence was 40 J/cm2. Demidova-Rice et al.11 evaluated the effects of laser therapy on excisional wounds and found that the dose effects are not linear for various fluences of 635-nm light, with a maximum positive effect at 2 J/cm2. They reported that intensities of 1 and 10 J/cm2 improved healing to a lesser extent, while 50 J/cm2 had a negative effect on wound healing. Using 670-nm laser therapy, treatment at 4 J/cm2 displayed superior wound healing than treatment at 8 J/cm2.12 Inadequate doses can result in weak and insignificant effects; while excessive doses can cause negative or minimal effects13. With even higher doses, a biosuppressive or inhibitory effect may be observed14. In contrast to these studies, we used 830-nm light and observed an optimal fluence of 40 J/cm2. As light at this wavelength can penetrate the skin more deeply, we hypothesize that a higher fluence of irradiation might be required for wound healing at 830 nm. Further study is needed to investigate whether over 40 J/cm2 of fluence of irradiation has harmful effect on wound healing.

Optical coherence tomography angiography

It’s important to keep up with your regular eye exams so your provider can keep track of changes in your vision. If you notice any unusual symptoms or vision changes, be sure to let your provider know.

OCTscan

Secure .gov websites use HTTPS A lock ( Lock Locked padlock icon ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Find many great new & used options and get the best deals for The Newest High Power Diode Laser Portable 808nm Laser Hair Removal Machine at the best online ...

Optical coherence tomography works similarly to ultrasound, another no-contact imaging method. Ultrasound (sonography) bounces inaudible sound waves off your tissues and measures the echo to create three-dimensional images. Similarly, OCT imaging bounces invisible red light off your tissues and measures them as they bounce back. This produces three-dimensional, cross-sectional images.

Your eye care specialist will evaluate the images from your ocular coherence tomography scan. If they’ve taken previous scans, they’ll compare the images. They’ll discuss their findings with you as soon as they can. Their findings can confirm if you have a condition affecting your retina or optic nerve, and how advanced it is. Your provider will use this information to plan the next steps in your treatment.

The most effective fluence level was 40 J/cm2 at day 5, as determined by monitoring wound closure. There were no statistically significant differences in wound healing with different durations.

InfraRed is an international infrastructure investment manager investing in assets that are critical to the functioning of societies.

Low-level laser (light) therapy (LLLT) is a promising technology used in various fields to stimulate healing, relieve pain and inflammation, and restore function to injured body parts. Since the initial experiments in 1983 studying the effects of low-level HeNe laser irradiation on wounds in rats, many studies have investigated wound healing by LLLT1.

Values are presented as mean (standard deviation). NA: not applicable, IR5: 5 days of irradiation, IR10: 10 days of irradiation, IR15: 15 days of irradiation. *p-values are obtained by using ANOVA.

An optical coherence tomography test is a quick and easy imaging test that can help your provider see to the back of your eyeball. It provides three-dimensional images of the different layers in your eye. This helps them take measurements and examine your optic nerve for potential damage. OCT can help your provider diagnose conditions that may be affecting your vision and can help them plan your treatment.

Optical coherence tomography machine

Fiber optic cable is made of many thin strands of coated glass fibers. Each measures about eight microns - that's smaller than a strand of human hair. Digitized ...

On days 1, 5, 10, and 15, images of the wounds were acquired, and the wound areas were measured as the primary outcome using Image-Pro Plus 6.0 software (Media Cybernetics, Silver Spring, MD, USA). The wound size immediately after wound creation was designated the original wound area. The percentage of wound closure at each time point was calculated using the following formula and defined as the secondary outcome.

Low-level laser (light) therapy is a promising technology that stimulates healing, relieves pain and inflammation, and restores function in injured body parts. However, few studies have compared the effects of light-emitting diodes of different fluence levels or different treatment durations.

In this study, we describe the effects of LLLT on wound size reduction in a standardized model of full-thickness excisional wound healing in mice, using an 830-nm diode laser with various fluence levels and durations of irradiation.

†Data are p-values, which are obtained by using t-test and corrected using the Bonferroni adjustment, which are significant when <0.05.

Optical coherence tomography

Official websites use .gov A .gov website belongs to an official government organization in the United States.

Optical coherence tomography (OCT) is a noninvasive imaging method that uses reflected light to create pictures of the back of your eye. It helps eye care providers diagnose and manage common eye diseases like diabetes-related retinopathy and glaucoma.

Corresponding author: You Chan Kim, Department of Dermatology, Ajou University School of Medicine, 164 World cup-ro, Yeongtong-gu, Suwon 16499, Korea. Tel: 82-31-219-5917, Fax: 82-31-216-9189, maychan@ajou.ac.kr

OCTeye test results

FUNDING SOURCE: This work was supported by the GRRC program of Gyeonggi province [GRRC아주2016B04, Development of medical devices using LED]. The GRRC program of Gyeonggi province had no involvement in study design; collection, analysis and interpretation of data; and writing the manuscript.

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

From full tables to accessories and replacement parts, your vibration, isolation and optical tables need to offer you consistency, accuracy and reliability ...

Articles from Annals of Dermatology are provided here courtesy of Korean Dermatological Association and Korean Society for Investigative Dermatology

Eight-week-old female albino hairless mice (Skh:hr-1) weighing 25∼30 g were maintained in individual ventilated cage systems. The animals were group-housed, ten mice per cage. Constant temperature, humidity, and a 12-hour light/dark cycle were maintained, and the mice were fed a standard diet. All experimental protocols were approved by the Committee for Animal Care and Use of Ajou University (approval no. 2017-0016).

by C Rivolta · 1986 · Cited by 20 — Equation (1) ; The encircled energy is defined as the fraction of the total energy contained within a circle of radius R centered at the optical axis in the ...

Eyepiece Tube holds the eyepieces in place above the objective lens. Binocular microscope heads typically incorporate a diopter adjustment ring that allows for ...

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

ANOVA was used to compare wound size reduction between treatment groups and the statistical analyses were performed using R software, version 3.5.2 (R Foundation for Statistical Computing, Vienna, Austria). p-values <0.05 were considered statistically significant. Summary data are expressed as the mean±standard deviation.

Polymer optical fibres, or POF for short, are all made of plastic. Thanks to the optical polymer fibres, also known as plastic fibres, POF fibre ...

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Sometimes, providers use OCT to look at the front of your eye, too. It can help them diagnose defects in the front of your eye or plan for eye surgery.

†Data are p-values, which are obtained by using t-test and corrected using the Bonferroni adjustment, which are significant when <0.05.

Regarding the wound healing of human skin, not only wound closure but also prevention of hypertrophic scars and keloids have great importance. In the context of formation of hypertrophic scar, the remodeling phase has critical role. Fibroblastic proliferation and excess collagen deposits are their two main characteristics, and imbalances in the rates of collagen biosynthesis and degradation, along with individual genetic predisposition, have been implicated in their pathogenesis21. It was recently proposed that poor regulation of interleukin (IL)-6 signaling and TGF β1 expression may play a significant role in this process22,23,24,25. LLLT can decrease IL-6 mRNA levels26, and has been proposed as an alternative therapy for hypertrophic scars. In three case studies, Barolet and Boucher27 reported significant improvements to scars after LLLT following scar revision by surgery or CO2 laser ablation. In fact, the mice in our study did not show any hypertrophic scar or keloid. Therefore, it is difficult to evaluate the effectiveness of LLLT for prevention of hypertrophic scar or keloid. Through previous studies that we mentioned above, however, more than 5 days of irradiation of LLLT might be helpful to prevent formation of hypertrophic scar or keloid. Further studies to evaluate the effectiveness of LLLT for prevention of human hypertrophic scars or keloids are needed.

A few studies have directly compared the effects of different fluences of LLLT. Da Silva et al.6 investigated the effects of a 670 nm-wavelength laser on rats, by irradiating skin lesions with 0, 2, or 4 J/cm2 for 10 consecutive days. At 4 J/cm2, the re-epithelialization process was significantly faster than that in the other groups. A study using a 632.8 nm-wavelength laser reported that 3∼6 J/cm2 photostimulation facilitates the tissue repair process in diabetic wound healing by accelerating the rates of contraction and collagen production7. With irradiation at 830 nm, a preliminary investigation demonstrated that 5 J/cm2 LLLT improved wound healing, as measured by increased wound tensile strength8. A study in mice comparing the influences of 632.8, 785, and 830 nm lasers on burn wound healing found that treatment with 830 nm light at a fluence of 3 J/cm2 had profound effects on healing compared to untreated controls and mice treated with lasers of other wavelengths9. However, no studies have compared the effects of different fluences and irradiation durations on wound size reduction.

When used to examine your eye, optical coherence tomography is sometimes called ocular coherence tomography (ocular means eye-related). More recently, healthcare providers of other specialties have begun to use OCT to examine other tissues. OCT has provided a new way to look at blood vessels (angiography). Providers in cardiology, neurology and oncology have all found uses for OCT imaging.

Eye care specialists often use OCT to examine your retina and the optic nerve in the back of your eye. This helps them diagnose retinal diseases and related conditions that may affect your vision, including:

Optical coherence tomography (OCT) is a noninvasive imaging method that eye care specialists use to produce cross-sectional images of your eye. It works by measuring wavelengths of infrared light that reflect off the back of your eye (your retina). OCT allows eye specialists to examine your eye in layers and to measure the depth of important structures. This helps them diagnose and treat eye conditions.