[4] Dhama, Kuldeep et al. “Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values.” Frontiers in molecular biosciences vol. 6 91. 18 Oct. 2019, doi:10.3389/fmolb.2019.00091

MTF curve assumes a circular aperture; other aperture shapes will produce slightly different results. *A perfect lens is one whose detail is limited only by ...

Modulation transfer functionin Ophthalmology

The biochemical changes associated with stress clearly reflect the body’s shift into fight or flight mode and the mobilization of resources to fuel this response. It is important to resolve the changes that take place during acute stress and support the changes that can occur with prolonged stress and exhaustion Healthy lifestyle changes can factor into both stages.

[9] Vita, Roberto et al. “Stress triggers the onset and the recurrences of hyperthyroidism in patients with Graves' disease.” Endocrine vol. 48,1 (2015): 254-63. doi:10.1007/s12020-014-0289-8

where Tmax is the maximum transmittance of the grating and Tmin is the minimum  transmittance. When we look at the ratio of the transmission from the light and dark bars, we are measuring contrast. We can look at a sine wave grating in the same manner. Now, let’s assume that you have a sine wave grating of a specific frequency (u) and modulation (contrast), and its image is passed through a lens. The modulation of the image can now be measured. The modulation transfer function at a specific frequency, MTF(u), is defined as the modulation, Mi, of the image divided by the modulation of the object, Mo, and is described by the following:

The MTF of an ideal optical system (one with no loss of contrast, or detail) would be a horizontal line. Of course, this is impossible to achieve. At some point, the MTF becomes 0; which is known as the cutoff frequency. A SWG with a frequency exceeding the cutoff will image as uniform gray, with no variation in contrast. In other words, SWGs with frequencies above the cutoff do not appear in the image. SWGs with frequencies below the cutoff appear in the image, but at reduced contrast when compared to the original. The cutoff frequency roughly corresponds to the resolution.  The MTF gives a more complete evaluation of optical performance than resolution, but it is harder to measure and interpret.

Modulation transfer functionmtf

[7] Noland, Diana, Jeanne A. Drisko, and Leigh Wagner, eds. Integrative and functional medical nutrition therapy: principles and practices. Springer Nature, 2020.

Ultimately, stress manifests as an increase in blood glucose, blood pressure, heart rate, cardiac contractility, and pupil dilation, and a decrease in gastrointestinal function. Prolongation of this sympathetic nervous system activation can become detrimental and damage tissues and organs.[3]

Unlike a sine wave grating, which gradually changes from dark to light, another pattern, known as Ronchi rulings, change abruptly and is instead is based on a square wave rather than a sine wave. Snellen figures (the standard visual acuity eye chart) are essentially Ronchi rulings. This is why Snellen acuity is such a poor way to asses visual performance. Contrast sensitivity testing, using charts that are basically SWGs, provides a more complete evaluation of visual performance, but this is a more complicated test to administer and is poorly understood by those outside of optics and ophthalmology, such as insurance companies.

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Modulation transfer functionmatlab

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As stated above, the difference between the bending of paraxial rays and the marginal rays is the amount of either positive or negative spherical aberration. The human cornea has naturally occurring positive spherical aberration and the human lens as naturally occurring negative spherical aberration. The net result is that these two structures together produce an optical system with a very low amount of positive spherical aberration. But if an older style spherical intraocular lens is implanted (which has positive spherical aberration) this increases the total amount of spherical aberration and degrades the image quality at larger pupil sizes.

by DL Jow · 2023 · Cited by 16 — Based on these definitions given, we will identify these two approximations with diffractive and refractive optics. Thus, contrary to what has previously been ...

Modulation transfer functionin optics

The human eye can be thought of in the same way as any optical system, with two basic components: the cornea and the lens. The cornea is an optical structure with positive spherical aberration and the lens is an optical structure with negative spherical aberration. The lens, with its negative spherical aberration greatly reduces the effect of the positive spherical aberration of the cornea.

[1] Burford, Natalie G et al. “Hypothalamic-Pituitary-Adrenal Axis Modulation of Glucocorticoids in the Cardiovascular System.” International journal of molecular sciences vol. 18,10 2150. 16 Oct. 2017, doi:10.3390/ijms18102150

Welcome to part 7 of the ODX Stress Biomarkers Series. In this post, the ODX Research team the major biomarkers and patterns associated with stress, including those reflecting acute and chronic stress, oxidative stress, and inflammation.

[2] Nater, Urs M et al. “Biomarkers of stress in behavioural medicine.” Current opinion in psychiatry vol. 26,5 (2013): 440-5. doi:10.1097/YCO.0b013e328363b4ed

Modulation transfer functionradiology

The modulation transfer function (MTF) is an optical bench measurement used by engineers to evaluate the performance of a lens, or a lens system. In its most basic sense, the MTF is a way to describe the contrast sensitivity of a lens system. For the human eye, this could be though of as its “visual performance.”

Modulation transfer functionimage processing

The greater the power of a spherical intraocular lens, the more spherical aberration it will produce. And the more the spherical aberration, the more the MTF is degraded, almost like unwanted noise in a poor quality sound recording. With an intraocular lens of a non-physiologic power, such as +35.00 diopters, there is an increase in spherical aberration on the order of the square of each doubling of diopteric strength.  This means that there is roughly four times as much spherical aberration for a +35.00 diopter intraocular lens as there would be at an intraocular lens implant power of +17.50 diopters.

[8] Ranabir, Salam, and K Reetu. “Stress and hormones.” Indian journal of endocrinology and metabolism vol. 15,1 (2011): 18-22. doi:10.4103/2230-8210.77573

[3] Piazza, Jennifer R et al. “Frontiers in the use of biomarkers of health in research on stress and aging.” The journals of gerontology. Series B, Psychological sciences and social sciences vol. 65,5 (2010): 513-25. doi:10.1093/geronb/gbq049

[10] Wardle, Jon, and Jerome Sarris. Clinical naturopathy: an evidence-based guide to practice. Elsevier Health Sciences, 2019. 3rd edition.

Optical images of any kind can be analyzed in much the same way. The difficult part here is that the optical analogy of a pure tone is a sine wave grating, or SWG. The frequency of the sine wave grating is determined by the horizontal peak-to-peak distance. The sine wave grating contrast is indicated by the difference in brightness between the brightest and darkest points, and is analogous to the volume of a tone. One difference between sound and optics is that SWGs also have an orientation, which can be vertical, horizontal, or oblique.

If a single pure tone is recorded, the frequency of the recording matches the frequency of the original, but the recorded volume usually changes. The ratio of the recorded volume to the original volume would be the measured response of an audio system to that particular frequency. If an audio system has different responses to different frequencies, the recorded sound will not match the original. However, if the audio system has the same response to all frequencies, the recorded sound will duplicate the original sound. A graph of response vs. frequency, known as a frequency response curve, is typically constructed to show the fidelity, or frequency response of any audio system. High-end audiophiles spend much of their time (and most of their money) chasing this.

Modulation transfer functionCT

Overall, improving the modulation transfer function of the human eye represents an attempt to achieve the best possible visual experience. The newest generation of intraocular lenses, such as the IQ lens attempt to do this based on the above scientific principles.

Now back to the audio analogy.  Just as a typical sound is a mixture of many pure frequencies, optical images are also mixtures of many SWGs. The image of a single SWG has the same frequency and orientation as the original SWG, but the contrast is always decreased. The ratio of the image SWG contrast and the object SWG contrast is the transfer factor. The transfer factor is always between 0 and 1 and different frequencies have different transfer factors.  The graph of transfer factor vs. frequency is the modulation transfer function and is analogous to the frequency response curve of an audio system.

Intraocular lenses used in ophthalmic surgery are generally spherical, are made of either silicone or plastic and have a single index of refraction. They are also not generally aspheric, and as such produce positive spherical aberration due to the fact that pencils of light traveling through the visual axis (known as paraxial rays) are bent less than those that travel through an area away from the visual axis (known as marginal rays).

Mar 5, 2022 — If you turn it round, or if light is coming in from the right, the shape factor is +0.38, and the spherical aberration is not at a minimum. Mind ...

Compressed Air is used to clean optical components with directed bursts of dry air. Compressed Air uses nozzles to concentrate bursts of moisture-free air to ...

[5] Pagana, Kathleen Deska; Pagana, Timothy J.; Pagana, Theresa N. Mosby's Diagnostic and Laboratory Test Reference. Elsevier Health Sciences. 2019.

Defining Depth of Field: ... The three factors affecting DoF explained: ... Depth of Field (DoF) refers to the distance between the closest and farthest objects ...

Recognition of the patterns associated with acute or chronic stress may help address which phase of the stress response an individual is experiencing. Note the biomarker shifts as one transitions from acute to chronic stress:

Feb 28, 2019 — Canon's first mount was a standard-thread-type screw mount that supported the mechanisms found in rangefinder cameras. Subsequent mounts evolved ...

When a sound is recorded, each component frequency gets recorded, but the process invariably changes the volume of each frequency. The playback is a mixture of tones that constitute the original sound, but usually at different volumes. This change in volume for a specific tone causes the recorded sound to differ from the original. Likewise, when an image is projected or recorded, the contrast is typically differs from the original object by small or large amounts.

Modulation transfer functionformula

Modulation transfer is the ability of a lens system to transfer an object’s contrast to its image.  Modulation is therefore a ratio of image contrast to object contrast. Ideally, it would be one, or 100%. Modulation transfer plots describe the modulation of a lens system as the object increases in complexity. Therefore, the Y-axis is modulation and the X-axis is spatial frequency, measured in line pairs per millimeter. As you would expect, as the spatial frequency increases, the modulation of any lens system decreases. Outside of optical engineering, most are unfamiliar with the importance of MTF because there are no easy ways to standardize it.

The most common way that MTF is explained is as an analogy to sound. Just as in optical imaging, audio recordings do not perfectly duplicate the original. A sound consists of many individual frequencies, or pure tones, simultaneously reaching the ear. Two parameters characterize a pure tone: the frequency, or tone, and the loudness, or volume.  A pure tone is typically represented by a sine wave.  The horizontal distance between peaks determines the frequency and a vertical distance from peak to valley determines the volume. Of course, most sounds are a mixture of many hundreds of different frequencies, each with its own volume. This would be a complex sound. In much the same way, an optical image is made up of many spacial frequencies and differing amounts of contrast.

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East Valley Ophthalmology offers comprehensive eye exams and world-class eye surgery using state-of-the-art medical procedures designed to enhance your life through better vision.

A biomarker reflects underlying physiology and reflects either homeostasis or dysfunction. Blood chemistry biomarkers that reflect HPA axis activity and the physiological stress response include cortisol and DHEA/DHEA-S, corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH), anti-diuretic hormone (also known as vasopressin or arginine vasopressin), epinephrine, norepinephrine, and aldosterone. Prolonged stress can also prolong disruption to the HPA axis and promote metabolic and cardiovascular consequences.[1]

For a Ronchi rulings there are basically dark bars and light bars and we can measure the amount of light coming from each. The maximum amount of light will come from the light bars and the minimum from the dark bars. If the light in a lens system is measured in terms of transmittance (T) we can define modulation according to the following equation:

[11] Noushad, Shamoon et al. “Physiological biomarkers of chronic stress: A systematic review.” International journal of health sciences vol. 15,5 (2021): 46-59.