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Focal neurologic signs also known as focal neurological deficits or focal CNS signs are impairments of nerve, spinal cord, or brain function that affects a specific region of the body, e.g. weakness in the left arm, the right leg, paresis, or plegia.[citation needed]

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Brainstem signs can involve a host of specific sensory and motor abnormalities, depending on which fiber tracts and cranial nerve nuclei are affected.[citation needed]

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Frontal lobe signs usually involve the motor system and may include many special types of deficit, depending on which part of the frontal lobe is affected:[citation needed]

Focal neurological deficits may be caused by a variety of medical conditions such as head trauma,[1] tumors or stroke; or by various diseases such as meningitis or encephalitis or as a side effect of certain medications such as those used in anesthesia.[2]

Neurological soft signs (NSS) are a group of minor non-focal neurological signs that include synkinesis.[3] Other soft signs including clumsiness, and loss of fine motor movement are also commonly found in schizophrenia.[4] NSS likely reflect impairments in sensory integration, motor coordination, and the carrying out of complex motor tasks.[3] When associated with schizophrenia the signs stop if clinical symptoms are effectively treated; and a consensus suggests that they may constitute a state marker for schizophrenia.[3]