Stein has a bunch of different business models mapped out for the company; ideally, he hopes to partner with high-cost specialty drugs to deliver medications in the AdhereTech bottle directly from pharmacies. Alternatively, patients could dump pills from a regular bottle into the AdhereTech bottle, possibly in exchange for rewards from insurance companies who are monitoring adherence.

First up for AdhereTech: a trial this summer with Walter Reed Army Medical Center that will pit the company's bottles against control groups for type 2 diabetes patients to see which solution is best for adherence. More trials will come soon after that.

Founded in 2021, ZEB Metals is a buyer and trader of non-ferrous scrap, as well as a recycler of metals other than iron and steel, according to the release. The company processes metals through shredding, melting, screening and sorting materials while providing full-service metal recycling including industrial clean-up and off-site demolition.

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A company that buys and trades non-ferrous scrap and also recycles metals and other material will establish its first South Carolina operations with a location in Berkeley County.

Relocating operations from Kentucky to a facility near Highway 52 in Moncks Corner, ZEB Metals’ new facility will process dross and other types of secondary aluminum scrap that would otherwise be destined for a landfill, according to the release. This is the first secondary re-melt facility of its kind in the Southeast region of the United States.

“Glencore and ZEB Metals are welcome additions to Berkeley County’s aluminum production sector,” Mike Fuller, Charleston Regional Development Alliance board chairman and president and CEO of Berkeley Electric Cooperative, said in the release. “They are also part of the growing industrial recycling effort in our state, which better secures our supply of critical materials and provides energy savings compared to the manufacturing of raw materials.”

The bottle is mindlessly simple to use, according to Stein. "Grandma would use it like a normal bottle. She picks it up from the pharmacy, and if she forgets her pills, she gets an automated phone call. The wireless module inside the bottle automatically connects to the cloud, where patients have access to all their medication adherence data. They can choose between receiving a call, text, an email, or a blinking light reminder to take their pills.

How do you solve the massive problem of people who don't take their medication correctly, endangering themselves and causing headaches for insurance companies? Startup Mango Health has taken the software route, creating a well-designed app that reminds patients to take their medication. A new company calledAdhereTechis taking a different approach: a smart pill bottle that leverages the same technology found in cell phones to ensure that patients don't forget their pills.

Charleston business is the market leader in business media in South Carolina. We connect you with decision-makers and stakeholders throughout the state.

AdhereTech's open API means that patients will be able to insert their data into apps and sync it with medical devices (i.e. glucose monitors). AdhereTech will have its own UI, but the bottle's strength lies in its ability to interact with other products.

The AdhereTech pill bottle is full of sensors and a mobile phone. When it's time to take your pills, it will remind you. And it knows if you forget to take them entirely. And then it will bug you even more.

"We're building a cell phone into the bottle," explains Josh Stein, CEO of AdhereTech. The high-tech bottle, based on technology from the University of Alabama, features wireless connectivity, sensors that measure humidity along with exactly how many pills (or liquid doses of medication) are left, blinking lights, and a battery that lasts 45 days.

There's no doubt that AdhereTech, which has raised $200,000 in seed funding, is tapping a big market. As Stein points out, "Even small increases in adherence lead to increased revenue for pharma companies and [better] health outcomes for patients." But each bottle currently costs $60, so the technology will only make sense in the foreseeable future for high-cost drugs that have pricey negative consequences when pills are missed.

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ZEB Metals, as part of a newly established joint venture with Glencore, is expected to create 28 jobs with its new facility, according to a news release from the South Carolina Department of Commerce.

The Coordinating Council for Economic Development awarded a $75,000 Set-Aside grant to Berkeley County to assist with site preparation and building construction, according to the release.

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“ZEB Metals is very excited about relocating our company to the Lowcountry and cannot wait to be a part of the community,” ZEB Metals President and CEO Cole Lanham said in the release. “South Carolina brings a unique opportunity in the recycling space with local businesses and government support. We’d like to thank everyone at Berkeley County for all their help in making this project come to life.”

Glencore, a Swiss-based commodities trader and one of the world’s largest diversified natural resource companies, will partner with ZEB Metals to expand its current aluminum portfolio, the release stated. The joint venture will allow for the development of a new line of recycled products to support the companies’ regional customer base.

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There are other smart pill bottles out there, but they don't have all the functionality of AdhereTech's model. "Other products measure when the bottle is moved, a cap is opened or closed and assume the correct dose was taken. We measure the contents and the open and close. The sensor knows how many pills are left," says Stein. "And other solutions require patients to change the way they change their medicine."

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