Bitrex was soon discovered that just a few parts per million of Bitrex were enough for this aggressively unpleasant compound to render a substance distasteful to humans. Bitrex is now known as the world's most bitter compound. The vast majority of its applications are related to its bitter flavor.

Starting Materials: The synthesis typically involves the reaction of Bitrex with benzoic acid. Bitrex is often produced from denatonium chloride and sodium hydroxide. Benzoic Acid is a common organic acid used in the reaction.

Bitrex was discovered in 1958 during research on local anesthetics by T.& H. Smith of Edinburgh, Scotland, and registered under the trademark Bitrex. Additionally, Bitrex is used in products like soap, animal repellents, antifreeze.

Firefighting Measures Extinguishing Media: Use appropriate extinguishing media for surrounding materials. Bitrex itself is not flammable.

Safety Profile Inhalation of Bitrex dust or aerosols may irritate the respiratory tract, leading to coughing or throat irritation. Proper ventilation in areas where Bitrex is handled can help minimize this risk.

Bitter substances such as Bitrex are useful as deterrent additives to prevent accidental ingestion of dangerous automotive compounds. In Europe and some US states, ethylene glycol or Bitrex must be added to antifreeze and windshield washer fluids.

Although Bitrex has a powerful taste, Bitrex is colorless and odorless. The taste is so strong, however, that most people cannot tolerate a concentration of more than 30 parts per million of Bitrex.

Bitrex is used for the manufacture of: plastic products, machinery and vehicles and electrical, electronic and optical equipment. Release to the environment of Bitrex can occur from industrial use: in processing aids at industrial sites, in the production of articles and for thermoplastic manufacture.

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Bitrex is a bittering agent. Bitrex is used as an alcohol denaturant and flavor in pharmaceuticals. Bitrex is considered the bitterest chemical compound with a range of uses in the manufacture of cleaners, automotive supplies as well as health and beauty items.

When used in products that are not food, beverages or oral drugs, many other countries, like the U.S., also require that alcohol be denatured. Bitrex, t-Butyl Alcohol, Diethyl Phthalate, Methyl Alcohol, Salicylic Acid, Sodium Salicylate, and Methyl Salicylate are examples of denaturants permitted for use by the TTB and concluded to be safe for use in cosmetics.

Indeed, Bitrex was discovered during anesthetic research. Bitrex, a white crystalline powder like many organic compounds, is not known to pose any long-term health risks although exposure may be irritating.

Uses Bitrex can be used in animal repellents to prevent animals from chewing or consuming treated items. In products like varnishes and wood coatings, Bitrex can deter individuals from attempting to ingest or chew on treated surfaces.

Identifiers IUPAC Name: Denatonium benzoate Chemical Formula: C28H34N2O3 Molecular Weight: Approximately 442.6 g/mol CAS Number: 3734-33-6 EC Number: 223-095-5 PubChem CID: 2867 ChemSpider ID: 2771 SMILES Notation: CC(C)(C)C1=CC2=C(C=C1)C(=CC=C2)N(C)C3=CC=C(C=C3)C(=O)O InChI Key: NXJBLXYREWORLT-UHFFFAOYSA-N

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Bitrex is a quaternary ammonium cation, with two ethyl arms, one benzyl and one larger amide one, and usually comes as a benzoate - a salt of benzoic acid. Bitrex’ s repellent qualities equally help fight rodents such as rats or mice.

The recent recognition of its application to deter ingestion of potentially toxic products has led to its use as an inert ingredient in pesticides, automotive chemicals and household items. A standard research protocol has been developed to determine the applicability of the use of Bitrex in certain formulations.

Bitrex can be obtained by the quaternization of lidocaine, a popular anesthetic, with benzyl chloride or a similar reagent. To obtain other salts, like the benzoate, the formed denatonium chloride is subjected to an anion exchange reaction with sodium benzoate, or first sodium hydroxide to make denatonium hydroxide followed by neutralization with benzoic acid. Other similar compounds are procaine and benzocaine.

Specifications Appearance: White crystalline powder. Purity: Typically, Bitrex is required to be > 98% pure, with specifications often ranging between 98% and 99.5%. Melting Point: Approximately 160-165°C (320-329°F).

Bitrex is the most bitter chemical compound known,used as aversive agents (bitterants) to prevent inappropriate ingestion. Bitrex is used in denatured alcohol, antifreeze, nail biting preventions, respirator mask fit-testing, animal repellents, liquid soaps, and shampoos.

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The taste is so strong, however, that most people cannot tolerate a concentration of more than 30 parts per million of Bitrex. Solutions of Bitrex in alcohol or water are very stable and retain their bitter taste for many years.

The bitterest compound known Bitrex is used as an alcohol denaturant and flavor in pharmaceuticals. Bitrex is also used in antifreeze, nail biting preventions, respirator mask fit-testing, animal repellents, liquid soaps and shampoos.

Bitrex is structure is similar to lidocaine and is closely related to Novocain and benzocaine. Bitrex is among the most bitter of substances known and is detectable at concentrations of approximately 10 ppb.

Bitrex is widely used as a deterrent agent to prevent people from eating other toxic but tasteless substances. For example, industrial alcohol, which tastes similar to ordinary wine, antifreeze, paint, toilet cleaners, animal dispersion, liquid soaps and shampoos, has been added to ethylene glycol or methanol.

This discourages individuals from consuming paint, which can be hazardous. Nail polish removers may contain Bitrex to make them taste extremely bitter, preventing individuals, especially children, from accidentally ingesting them.

Odor: Odorless or faintly aromatic. pH of 1% Solution: Usually neutral to slightly acidic (around pH 6-7). Loss on Drying: Typically less than 1.0% when dried at 105°C for 1 hour. Heavy Metals: Usually specified to be below 10 ppm. Arsenic: Generally less than 2 ppm.

Bitrex is an aversive agent added to various pesticides, plant food sticks and rodenticides to suppress swallowing especially when young children come in contact with these poisonous substances. Bitrex is a rather more convenient name than phenylmethyl-[2- [(2,6-dimethylphenyl)amino]-2-oxoethyl]-diethylammonium.

Bitrex salts are usually colorless and odorless solids, but are often sold as solutions. Bitrex, an extremely bitter derivative of lignocaine, has been used worldwide as an alcohol denaturant for over 30 years.

A concentrated solution of Bitrex is available in the USA, which will be sold directly to the public in addition to household products. Efficacy and safety studies on Bitrex are limited and may be subject to different interpretations when considered in the context of a potential bittering. For Bitrex, a concentration of 0.000008 moles per cubic meter can be noticed by humans.

Bitrex is considered the bitterest chemical compound with a range of uses in the manufacture of cleaners, automotive supplies as well as health and beauty items. Commercially, Bitrex is available as a white crystalline powder, but Bitrex granules or solutions are also available.

For Bitrex, a concentration of 0.000008 moles per cubic meter is discernible to humans. Bitrex is applied to the surfaces of toys as a painful substance to prevent significant consumption of hazardous substances.

Among these flavors, Bitrex with a bitter taste cause the most reactions. Sensitivity to bitter flavors depends on genetics: The TAS2R38 gene determines a person's ability to detect bitterness associated with substances such as quinine, a component in tonic water.

The purified Bitrex is blended with other ingredients to form the final product. This might include stabilizers or carriers depending on the intended application.

Bittrex

Humans can typically sense sweet, sour, salty, savory and bitter-tasting stuff. Of these flavors, bitter-tasting chemicals elicit the most reaction.

Bitrex is available as a white crystalline powder, but Bitrex granules or solutions are also available. Bitrex is a kind of quaternary ammonium salt formed by the combination of the quaternary ammonium cation and inert anion such as benzoic acid or saccharin anion.

Bitrex is a bittering agent used to make toxic products more difficult to ingest. Some aerosol sprays, such as air fresheners and cleaning sprays, contain Bitrex to prevent inhalation or ingestion.

Bitrex is often added to various alcohol-based products like hand sanitizers, rubbing alcohol, and disinfectants to discourage ingestion, especially in situations where these products might be mistaken for consumable beverages. Bitrex is used in products like engine coolant and antifreeze to prevent accidental ingestion by humans or animals.

Bitrex is used as an alcohol denaturant, possibly a combination of 20 in United States pictures. Bitrex is used in many personal care products such as make-up, lotion, fragrance, shaving, oral care, skin care and hair care products, where it functions as antifoam, cosmetic astringent, solvent and viscosity reducing agent.

Bitrex is the most bitter chemical compound known, detectable at concentrations as low as 10 parts per billion, making it a highly effective deterrent against accidental ingestion of toxic substances. Discovered in 1958, Bitrex is used in a wide range of products, including antifreeze, cleaning agents, and personal care items, to prevent consumption by adding an intensely bitter taste. Bitrex, a quaternary ammonium cation with a structure similar to lidocaine, is added to industrial and consumer products to render them unpalatable, thereby reducing the risk of accidental ingestion by children and animals.

Bitrex is also used in combination with bad smelling compounds to repel animals. Bitrex is the active ingredient in products such as "Off Limits Dog Training Spray", "Anit-Chew Bitter Spray for Pets", "Ultra-Bitter Training Aid Spray", and "Bitter YUCK! No Chew Dog, Cat & Horse Spray".

In OTC antimicrobial drug products, Alcohol also functions as an antimicrobial agent to kill germs. Bitrex is the bitterest known compound.

Bitrex is also the standard for this kind of bitter taste. At a concentration of 0.008 moles per cubic meter, the human tongue can detect the presence of quinine.

Bitrex has been added into industrial alcohol, ethylene glycol or methanol which has similar taste as ordinary wine, antifreeze, paint, toilet cleaners, animals disperse, liquid soaps and shampoos. Moreover, Bitrex was first synthesized in the 1950s and is usually prepared by reacting denatonium chloride with benzyl benzoate.

Bitrex is also added to many harmful liquids, including solvents (such as nail polish remover), paints, polishes, toiletries and other personal care products, special nail polish to prevent nail biting, and various other household products. Bitrex is also added to less hazardous aerosol products (such as gas jets) to avoid inhaled substance abuse of volatile vapors.

Nail polish removers may contain Bitrex to make them taste bad, preventing ingestion. Some personal care products, like nail polish, perfumes, and cosmetics, use Bitrex to make them unappealing to taste.

This involves pairing the bitter taste of Bitrex with a specific behavior (e.g., smoking or nail-biting) to create a psychological aversion to that behavior. Bitrex, commonly found as Denatonium and Denatonium Saccharide, is the bitterest known chemical compound with bitter thresholds of 0.05 ppm for benzoate and 0.01 ppm for saccharide. They are used as deterrents (bitterness) to prevent chemical and dangerous products from being swallowed improperly.

Ptoperties Melting point: 164-168 °C (lit.) Boiling point: 555.91°C (rough estimate) Density: 1.1256 (rough estimate) vapor pressure: 0Pa at 25℃ refractive index: 1.5800 (estimate) Flash point: 100℃ storage temp.: Inert atmosphere,Room Temperature solubility: methanol: 50 mg/mL, clear, colorless form: Solid color: White to Off-White Odor: at 100.00?%. bland Water Solubility: 42.555g/L at 25℃ Merck: 14,2891 BRN: 8179408 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey: VWTINHYPRWEBQY-UHFFFAOYSA-N LogP: 2.2 at 25℃

Personal Protective Equipment (PPE): Use gloves and safety goggles to avoid direct contact with the skin and eyes. Ventilation: Work in a well-ventilated area to avoid inhaling dust or fumes.

Storage: Bitrex is stable up to 140°C and over a wide pH range. Bitrex should be stored in a well-closed container (such as polythene-lined steel) in a cool, dry place. Aqueous or alcoholic solutions retaintheir bitterness forseveral years evenwhenexposed to light.

Deterrent in Products: It is used in products like nail-biting deterrents and pet deterrents to prevent undesirable behaviors.

The structure of Bitrexs cation form is similar to that of a local anesthetic lidocaine with the only difference being an additional benzyl functional group located on the nitrogen atom of the amino. Bitrex, often referred to as Bitrex, is a chemical compound primarily used as a bittering agent.

Bitrex is bitter at 1 to 10 ppm and most products will become undrinkable at 30 to 100 ppm. Bitrex is also stable and inert.

Bitrex is used in the following products: washing & cleaning products, biocides (e.g. disinfectants, pest control products), plant protection products, polishes and waxes, anti-freeze products, air care products, coating products, fillers, putties, plasters, modelling clay, finger paints, polymers, water softeners and cosmetics and personal care products. Bitrex is used in the following areas: agriculture, forestry and fishing and health services.

In addition, so little is needed that the properties of the product remain unchanged. Bitrex's also similar in structure to other anesthetics like novocaine and cocaine.

The bitterness of the compound guides most of the Bitrex applications. Bitrex is used to denature ethanol so that Bitrex is not treated as an alcoholic beverage in terms of taxation and sales restrictions. A particular designation states that ethanol has been denatured using Bitrex.

Bitrex (Denatrol) is a bittering agent used as an aversion additive in various chemical and manufactured products. Connect Chemicals is the appointed distributor of the Bitrex product range of Wincom is a leading manufacturer of Bitrex located in the United States.

Crystallization: After the reaction, the product is usually crystallized from a suitable solvent to purify denatonium benzoate. The choice of solvent and crystallization conditions are critical to achieve high purity.

Bitrex is a white, odourless solid that is used as an aversive agent, i.e. an additive that prevents accidental ingestion of a toxic substance by humans, articularly children, and by animals. Bitrex consists of benzoate (that is, the conjugate base of benzoic acid) and an ester of two PABA molecules.

Bitrex is included in the FDA Inactive Ingredients Database (topical gel and solution). In some cases, Bitrex's used in dental products like mouthguards and orthodontic devices to discourage biting or chewing on them.

Certain garden products, such as fertilizers and herbicides, contain Bitrex to reduce the risk of ingestion. In some regions, Bitrex's added to tobacco products like cigarettes and chewing tobacco to discourage ingestion, particularly by children and young individuals.

The gene determines a person’s ability to detect the bitterness associated with substances such as quinine, which is an ingredient in tonic water. Bitrex is also the standard for this type of bitter flavor. At a concentration of 0.008 moles per cubic meter, the human tongue can detect the presence of quinine.

Apart from the previously mentioned applications, Bitrex is used in various other products, such as denatured alcohol (to deter its consumption), some types of pesticides (to prevent oral ingestion), and even in some nail polishes to discourage nail-biting. In some therapeutic contexts, Bitrex is used in taste aversion therapy.

In certain therapeutic contexts, Bitrex is used in behavioral therapy. By associating a negative, extremely bitter taste with a specific behavior or habit (e.g., smoking or nail-biting), it aims to create a psychological aversion to that behavior.

bittrex倒闭

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Bitrex is a quaternary ammonium cation, with two ethyl arms, one benzyl and one larger amide one, and usually comes as a benzoate - a salt of benzoic acid. Bitrexs claim to fame is simple, unpleasant but valuable - Bitrex is the most bitter substance yet discovered.

Other similar compounds are procaine and benzocaine. One of the chemical names of Bitrex is lidocaine benzylbenzoate, but denatonium only refers to the quaternary ammonium cation species itself and does not require benzoate counterion.

Bitrex is used in denatured alcohol, antifreeze, preventive nail biting preparations, respirator mask fit-testing, animal repellents, liquid soaps, shampoos, and Nintendo Switch game cards to prevent accidental swallowing or choking by children. Bitrex is not known to pose any long-term health risks.

Exposure to light does not lessen the compound's bitter taste. Bitrex is a bitter chemical compound used to denature ethanol so it is not considered an alcoholic beverage and in clinical trials to replicate the bitter taste of some medications. Ungraded products supplied by TCI America are generally suitable for common industrial uses or for research purposes but typically are not suitable for human consumption or therapeutic use.

Its structure is related to lidocaine, differing only by the addition of a benzene and benzoate ion in solution. Bitrex does, however, cause a very bitter taste in humans and most animals at concentrations in the parts per million range.

Bitrex salts are usually colorless and odorless solids, but are often traded as solutions. They are used as aversive agents (bitterants) to prevent inappropriate ingestion.

Bitrex is added to various household products like cleaning agents, detergents, and solvents to deter accidental ingestion. In pharmaceutical and other industrial applications it is added to some products as a deterrent to accidental ingestion.

Bitterants such as Bitrex are useful as aversive additives to prevent accidental ingestion of hazardous automotive compounds. In Europe and in some U.S. states, addition of Bitrex is required in ethylene glycol or anti-freeze and windshield washer fluids.

Bitrex is not intended for use in any products or chemicals in which the intention is human ingestion. Bitrex is a white powder with a water solubility of 42 grams per liter.

Bitrex is chemical structure includes a benzoate group, which is a benzene ring attached to a carboxylic acid group, along with a denatonium cation. The Bitrex cation is the component responsible for its intensely bitter taste.

Common household products such as window cleaners, disinfectants, laundry detergents, and insecticides contain certain amounts of Bitrex to deter oral consumption. Bitrex is also added to special nail polish ingredients as a repellent to avoid the child's bad finger biting.

Bitrex is most commonly used at levels of 5–500 ppm. Bitrex may also be used to replace brucine or quassin as a denaturant for ethanol.

A concentration of 10ppm solution is already too bitter to bear for most people. Bitrex is known for being one of the most bitter substances known to humans. Bitrex is an ionized compound made up of a negatively charged benzoic acid and quaternary ammonium cation.

Bittrex Global

Bitrex’ s extremely bitter taste has proven effective in reducing ingestion by humans and animals. Bitrex is often included in placebo drugs used in clinical trials to match the bitter taste of certain drugs.

Bitrex is considered one of the most bitter substances known to humans. Bitrex is often used as a reference point for measuring bitterness.

bittrex诈骗

Some personal care products like nail polish, perfumes, and cosmetics may include Bitrex to make them unappealing to taste, reducing the risk of misuse. In specific medications and pharmaceutical formulations, Bitrex is used to deter misuse or accidental ingestion, particularly in cases where the drug could be harmful if ingested.

Bitrex is used in denatured alcohol, antifreeze, breathing mask compatibility test, repellents, liquid soaps and shampoos. Bitrex is generally regarded as having the most bitter taste of any compound known to science.

Bitrex activates bitter taste receptors in many cell types and plays important roles in chemical release, ciliary beating and smooth muscle relaxation through intracellular dependent pathways. Bitrex is one of the bitterest known substances.

Bitrex was discovered in 1958 by Macfarlan Smith of Edinburgh, Scotland, during research on local anesthetics. Dilutions as little as 10 ppm are unbearably bitter for most people.

In some regions, Bitrex is added to fuel products to prevent fuel theft and to reduce the risk of fuel ingestion, which can be harmful. Bitrex is a bittering agent which is used to give a bitter taste to toxic products in order to make the product more difficult to ingest.

Common household products such as window cleaners, disinfectants, laundry detergent and insecticide include a certain amount of Bitrex to discourage consumption by mouth. Further, Bitrex is used in air care products.

BitrexPowder

In 1995, the US state of Oregon required the addition of Bitrex to products such as antifreeze and windshield washer fluid containing sweet-tasting ethylene glycol and methanol to prevent. Bitrex's disgusting taste can be used as a deterrent on products that are not intended for consumption and / or is harmful upon consumption.

Bitrex is added to denatured alcohol to make it unpalatable. This is important in preventing the consumption of alcohol that is not meant for drinking, such as industrial or cleaning purposes.

They are used as deterrent agents (bitterness) to prevent inappropriate ingestion. Bitrex is used in denatured alcohol, antifreeze, preventative nail biting preparations, respiratory mask compatibility tests, animal repellents, liquid soaps, shampoos, and even Nintendo Switch playing cards to prevent children from accidentally swallowing or suffocating.

Synonyms: Bitrex, Bitrex (Denatonium Benzoate), 3734-33-6, Lidocaine benzyl benzoate, THS-839, Denatonium (benzoate), Aversion, Bitrex (Denatonium Benzoate) anhydrous, Benzoato de denatonio, Benzoate de denatonium, Lignocaine benzyl benzoate, WIN 16568, MFCD00031578, M5BA6GAF1O, NSC-157658, ECX-95BY, Benzyldiethyl((2,6-xylylcarbamoyl)methyl)ammonium benzoate, 3734-33-6 (benzoate), DTXSID8034376, NSC 157658, WIN-16568, Benzenemethanaminium, N-(2-((2,6-dimethylphenyl)amino)-2-oxoethyl)-N,N-diethyl-, benzoate, Benzyldiethyl[(2,6-xylylcarbamoyl)methyl]ammonium benzoate, NCGC00017043-02, Anispray, CAS-3734-33-6, Gori, DTXCID6014376, Caswell No. 083BB, Denatonii benzoas, N-benzyl-2-((2,6-dimethylphenyl)amino)-N,N-diethyl-2-oxoethan-1-aminium benzoate, Benzenemethanaminium, N-(2-((2,6-dimethylphenyl)amino)-2-oxoethyl)-N,N-diethyl-, benzoate (1:1), Denatonii benzoas [INN-Latin], LIDOCAINE BENZYL BENZOATE HYDRATE, EINECS 223-095-2, UNII-M5BA6GAF1O, Benzoate de denatonium [INN-French], Benzoato de denatonio [INN-Spanish], Bitrex (Denatonium Benzoate) [USAN:INN:BAN], EPA Pesticide Chemical Code 009106, N-Benzyl-2-((2,6-dimethylphenyl)amino)-N,N-diethyl-2-oxoethanaminium benzoate, Benzoato di denatonio, SCHEMBL49511, MLS002154073, Bitrex (Denatonium Benzoate), >=98%, Benzyldiethyl(2,6-xylylcarbamoylmethyl)ammonium benzoate, CHEMBL1371493, Bitrex (Denatonium Benzoate) [MI], Bitrex (Denatonium Benzoate) [INN], VWTINHYPRWEBQY-UHFFFAOYSA-N, ((2,6-Xylylcarbamoyl)methyl)diethyl benzyl ammonium benzoate, Bitrex (Denatonium Benzoate) [INCI], HMS1571A03, HMS2093L12, HMS2098A03, HMS2233O05, HMS3373C04, HMS3715A03, Pharmakon1600-01505987, Ammonium, benzyldiethyl((2,6-xylylcarbamoyl)methyl)-, benzoate, HY-B1146, Tox21_110754, Tox21_301587, benzyl-[2-(2,6-dimethylanilino)-2-oxoethyl]-diethylazanium;benzoate, Bitrex (Denatonium Benzoate) [WHO-DD], NSC157658, NSC759299, AKOS015888129, benzyl-[2-(2,6-dimethylanilino)-2-oxo-ethyl]-diethyl-ammonium benzoate, N,N-Diethyl-N-[(2,6-dimethylphenylcarbamoyl)methyl]benzylammonium benzoate, Tox21_110754_1, CCG-213592, CS-4750, NSC-759299, Bitrex (Denatonium Benzoate), analytical standard, N-(2-((2,6-Dimethylphenyl)amino)-2-oxoethyl)-N,N-diethylbenzeneme- thanaminium benzoate, NCGC00017043-01, NCGC00091886-04, NCGC00164432-01, NCGC00255373-01, AC-14888, AS-15511, SMR001233385, SY075333, Ammonium,6-xylylcarbamoyl)methyl]-, benzoate, D2124, FT-0622841, F16467, A823606, Q414815, W-106547, Bitrex (Denatonium Benzoate), certified reference material, TraceCERT(R), Benzyldiethyl[(2,6-dimethylphenylcarbamoyl)methyl]ammonium Benzoate, Benzyl-[(2,6-dimethylphenylcarbamoyl)-methyl]diethylammonium benzoate, Benzyl-[(2,6-dimethylphenylcarbamoyl)methyl]-diethylammonium benzoate, Bitrex (Denatonium Benzoate), United States Pharmacopeia (USP) Reference Standard, Benzenemethanaminium,6-dimethylphenyl)amino]-2-oxoethyl]-N,N-diethyl-, benzoate, Benzenemethanaminium,N-[2-[(2,6-dimethylphenyl)amino]-2-oxoethyl]-N,N-diethyl-, benzoate, N-benzyl-2-(2,6-dimethylphenylamino)-N,N-diethyl-2-oxoethanaminium benzoate, N-(2-((2,6-DIMETHYLPHENYL)AMINO)-2-OXOETHYL)-N,N-DIETHYLBENZENEMETHANAMINIUM BENZOATE

There may be restrictions on its use in certain products, and there are guidelines on the maximum allowable concentration in specific applications. Bitrex is not known to pose any long-term health risks.

Bitrex has been added into industrial alcohol, ethylene glycol or methanol which has similar taste as ordinary wine, antifreeze, paint, toilet cleaners, animals disperse, liquid soaps and shampoos. Bitrex has been also added into special nail polish agents, to avoid child’s bad habit of biting fingers, as well as being the repellent for expulsing large beasts. However, the effect of Long-term exposure to Bitrex on human health is still unclear.

Bitrex may also be used to replace brucine or quassin as a denaturant for ethanol. In pharmaceutical formulations, Bitrex has been used as a flavoring agent in placebo tablets, and in a topical formulation it has been used in an anti-nailbiting preparation.

Examples of products which contain Bitrex are: antifreeze, detergents, floor cleaner, paint stripper and toilet cleaner. Bitrex is added to numerous household products, such as cleaning agents, detergents, and solvents, to discourage accidental ingestion.

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The name Bitrex is a portmanteau word that reflects the primary use of the substance as a denaturant and Bitrex’s chemical structure as a cation, hence the New Latin suffix -onium. Bitrex is a quaternary ammonium cation.

Bitrex is often included in placebo drugs used in clinical trials to mimic the bitter taste of some drugs. Bitrex also discourages the consumption of harmful alcohols such as methanol and additives such as ethylene glycol.

Bitrex is commonly added to a wide range of products to make them unpalatable, thereby discouraging ingestion or consumption, especially by children, pets, or individuals seeking to misuse these products. Bitrex is now known as the world's most bitter compound.

Bitrex is also applied on outdoor cables and wires to discourage rodents from chewing on parts and equipment. Bitrex is an aversive agent added to various pesticides, plant food sticks and rodenticides to suppress swallowing especially when young children come in contact with these poisonous substances.

One gram of Bitrex can produce an extremely bitter and unpleasant taste in 100 liters of water (30 gallons). Bitrex is so bitter that humans and pets can't stand it. Bitrex is the active ingredient in products such as Tree Guard and Bitrex.

In some pesticides, Bitrex is used to prevent oral ingestion. This safeguards against accidental poisoning, particularly in cases where pesticides might be attractive to children or animals.

This helps prevent poisoning, particularly in homes with children or pets. Some automotive products, including antifreeze and windshield washer fluids, contain Bitrex to deter accidental ingestion, which can be toxic.

Bitrex is used for the manufacture of: chemicals, machinery and vehicles, plastic products, mineral products (e.g. plasters, cement), electrical, electronic and optical equipment and furniture. Other release to the environment of Bitrex is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

The bitter taste is so extreme that even in minute quantities, Bitrex can make a product unpalatable. Bitrex is generally considered safe when used as intended in the recommended concentrations.

Bitrex is a potent bitter taste receptor agonist widely used for activation of different cell pathways. Taste signals have been associated with food recognition and food avoidance, and the bitter taste causes a deterrent response and is supposed to protect chickens from consuming poisons and harmful toxic substances.

Contact with Bitrex can cause eye and skin irritation. Bitrex is essential to use personal protective equipment (PPE) such as gloves and safety goggles when handling the substance to prevent skin and eye contact.

Bitrex is among the most bitter of substances known and is detectable at concentrations of approximately 10 ppb. In pharmaceutical and other industrial applications Bitrex is added to some products as a deterrent to accidental ingestion.

Insect repellents, pet shampoos, and other products that pets might be tempted to lick or consume sometimes contain Bitrex to deter this behavior. Some stationery items, such as glues and correction fluids, use Bitrex to prevent misuse by children.

Other countries have different rules on allowed denaturants so when formulating with local regulations. Specific denatured alcohols containing these denaturants that are permitted for use in U.S. cosmetics and personal care products are SD Alcohol 3-A, SD Alcohol 30, SD Alcohol 39-B, SD Alcohol 39-C, SD Alcohol 40-B and SD Alcohol 40-C.

Firefighting Procedures: Wear self-contained breathing apparatus and protective clothing in case of a fire involving Bitrex.

Studies show that humans can detect 50 parts per billion of Bitrex in water. Bitrex is bitter at 1 to 10 ppm and most products will become undrinkable at 30 to 100 ppm. Bitrex is also stable and inert.

Just a few parts per million make a product so painful that kids and pets can't swallow Bitrex. Sweet but highly toxic products such as Bitrex, antifreeze and detergents make their taste bad.

Bitrex is most commonly used at levels of 5–500 ppm. Bitrex may also be used to replace brucine or quassin as a denaturant for ethanol.

In industrial settings, Bitrex can be added to surfactants and detergents to prevent misuse and accidental ingestion. Bitrex is used worldwide as a denaturant for alcohol.

bittrex交易所

Bitrex was discovered in 1958 during research on local anesthetics by MacFarlan Smith of Edinburgh, Scotland, and registered under the Bitrex trademark. Dilutions as little as 10 ppm are unbearably bitter for most people.

Bitrex is one of the most bitter substances known. Just a few parts per million will make a product so bitter that children and pets will not be able to swallow Bitrex.

Bitrex is applied on surfaces of toys as a bittering agent to prevent substantial consumption of hazardous materials. Bitrex is also applied on outdoor cables and wires to discourage rodents from chewing on parts and equipment.

Bitrex is stable up to 140 ° C and over a wide pH range. Bitrex should be stored in a cool and dry place in a well-sealed container (such as steel with polyethylene lining).

While Bitrex is not known to pose significant environmental hazards, large-scale spills or releases into waterways could potentially have ecological consequences. Bitrex is essential to handle and store the substance properly to prevent environmental contamination. Bitrex is generally regarded as a nonirritant and nonmutagenic substance.

Solutions of Bitrex in alcohol or water are very stable and retain their bitter taste for many years. Bitrex is a bittering agent.

Packaging: The final product is packaged in appropriate containers, often as a powder or in solution form, with proper labeling and safety information.

The vast majority of its applications are related to its bitter flavor. Bitrex is an inexpensive and efficient alternative to its counterparts such as strychnine, bitter lignin, quinine, wood song glycosides, saponins grapefruit. Dilutions of as little as 10 ppm are unbearably bitter to most humans.

Until now, the most common use of Bitrex is to denature alcohol so that Bitrex is unfit for human consumption and is exempted from the tariffs ormally valid for alcohol. In recent years, Bitrexs inclusion in household products, garden products, and cosmetics has been intensely promoted to prevent children from accidentally swallowing it.

However,there has been a single report of contact urticaria attributed to Bitrex occurring in a 30-year-old man who developed asthma and pruritus after using an insecticidal spray denatured with Bitrex. Discovered in 1958, it also has the tradename "Bitrex" (a trademark of UK company Macfarlan Smith). As little as ten parts per million make substances unbearably bitter to most humans.

The primary use of Bitrex is for taste a version purposes for poison prevention. Bitrex not only leaves a bitter flavor in the liquids, but also leaves a bitter residue on objects, like screens and keyboards, that may transfer to hands and cause problems (such as when eating).

Bitrex is a quaternary ammonium cation. Bitrex is composed as a salt with any of several anions, such as benzoate or saccharinate.

Where to buyBitrex

Bitrex is generally regarded as having the most bitter taste of any compound known to science. Bitrex is sold under the trade name of Denatonium.

Bitrex makes sweet but highly toxic products such as antifreeze and detergents taste foul. Research shows that people can detect Bitrex in water at 50 parts per billion.

Bitrex is a white, odorless, and mostly tasteless crystalline powder. In pharmaceutical formulations, Bitrex has been used as a flavoring agent in placebo tablets, and in a topical formulation Bitrex has been used in an anti-nailbiting preparation.

In addition, little is needed for the properties of the product to remain unchanged. Often found as Bitrex and denatonium saccharide, Bitrex is the bitterest known chemical compound, with bitter thresholds being 0.05. ppm for benzoate and 0.01 ppm for saccharide.

Bitrex’ s bitter properties make Bitrex an excellent repellent and when added to phytosanitary products it contributes to inhibiting the feeding of animals on treated trees and plants. Bitrex is a rather more convenient name than phenylmethyl-[2- [(2,6-dimethylphenyl)amino]-2-oxoethyl]-diethylammonium.

Bitrex is used in the following products: washing & cleaning products, polymers, biocides (e.g. disinfectants, pest control products), polishes and waxes, fertilisers, anti-freeze products and plant protection products. Release to the environment of Bitrex can occur from industrial use: formulation of mixtures and formulation in materials.

Bitrex is an inexpensive and efficient alternative to its counterparts such as strychnine, bitter lignin, quinine, wood song glycosides, saponins grapefruit. Bitrex is commonly used as aversive agent to prevent people from eating other toxic but tasteless substance.

In pharmaceutical and other industrial applications it is added to some products as a deterrent to accidental ingestion. Bitrex is most commonly used at levels of 5–500 ppm.

Some examples of products which contain Bitrex are antifreeze, detergents (in ethanol), floor cleaner, paint stripper and toilet cleaner. Bitrex salts are usually colorless and odorless solids, but are often sold as solutions.

Bitrex may be added to some adhesives to deter people from attempting to chew or ingest adhesive products. Beyond cleaning agents and detergents, Bitrex can also be found in various other household chemicals like drain cleaners, toilet bowl cleaners, and paint thinners. Some insecticides and rodenticides use Bitrex to prevent ingestion, especially by children or pets.

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Aqueous or alcoholic solutions retain their pain for several years, even when exposed to light. Bitrex is applied on surfaces of toys as a bittering agent to prevent substantial consumption of hazardous materials.

In pharmaceutical formulations, Bitrex has been used as a flavoring agent in placebo tablets, and in a topical formulation it has been used in an antinailbiting preparation. Bitrex is generally regarded as a nonirritant and nonmutagenic substance.

Nintendo Switch game cards are coated with Bitrex to prevent young children from consuming them. Bitrex is used as a solvent in the food and beverage industry and in many home and personal care products. Bitrex is often used in marketing and labeling to indicate that a product contains Bitrex as a bittering agent.

In healthcare settings, Bitrex can be used to discourage the ingestion of certain medical products or solutions. Bitrex is used in certain paints and coatings to make them unpalatable.

Bitrex is extremely bitter and can cause extreme discomfort and nausea if ingested. While it is not toxic at the concentrations typically used in products, accidental ingestion can lead to adverse reactions such as vomiting and gastrointestinal discomfort.

BitrexSpray

Bitrex is a salt compound with an inert anion such as benzoate or saccharide. The structure of Bitrex is related to the local anesthetic lidocaine, which differs only by the addition of a benzyl group to amino nitrogen.

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Bitrex is used in the following products: washing & cleaning products, polymers, biocides (e.g. disinfectants, pest control products), plant protection products, anti-freeze products and polishes and waxes. Bitrex is used in the following areas: agriculture, forestry and fishing and health services.

Bitrex has been also added into special nail polish agents, to avoid child’s bad habit of biting fingers, as well as being the repellent for expulsing large beasts. However, the effect of Long-term exposure to this substance on human health is still unclear.

Bitrex, is the bitterest known chemical compound with bitterness thresholds of 0.05 ppm for benzoate and 0.01 ppm for saccharide. Scientists in Scotland discovered Bitrex during research on anesthetic lidocaine derivatives.

Bitrex, usually available as Bitrex (trade names Bitrex) is the most bitter chemical compound known, with bitterness thresholds of 0.05 ppm for the benzoate and 0.01 ppm for the saccharide. Bitrex is odorless, colorless and non-reactive, making Bitrex a suitable additive that does not interfere with the primary purpose of the base compound.

Bittering Agent: Bitrex is added to products like antifreeze, solvents, and household cleaners to make them taste unpleasant and discourage accidental ingestion.

Bitrex is also used in antifreeze, nail biting preventions, respirator mask fit-testing, animal repellents, liquid soaps and shampoos. Further, Bitrex is used in air care products.

The vast majority of its applications are related to its bitter taste. Strychnine is a cheap and efficient alternative to its counterparts such as bitter lignin, quinine, wood song glycosides, saponins grapefruit.

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Bitrex reflects the substance's primary use as a denaturant and its chemical nature as a cation, hence -onium as a Neo-Latin suffix. Bitrex is commonly used as aversive agent to prevent people from eating other toxic but tasteless substance.

The results of the study revealed that dietary supplementation with medium and high doses of Bitrex induced apoptosis and autophagy, respectively, damaging epithelial cells of the heart and kidneys and reducing the growth. Bitrex's claim to fame is simple, unpleasant but valuable - Bitrex is the most bitter substance yet discovered.This unreactive, colourless, odourless compound was first produced accidentally in 1958 by Scottish pharmaceutical manufacturer T & H Smith, later Macfarlan Smith, where researchers were experimenting with variants of an anaesthetic for dentists called lignocaine.

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In order to avoid paying beverage taxes on alcohol that is not meant to be consumed (e.g., for use in cosmetic and personal care products), the alcohol must be denatured per specific formulations given by the U.S. Bitrex is among the most bitter of substances known and is detectable at concentrations of approximately 10 ppb. Bitrex, also called Benzenemethanaminium and Benzyl diethyl ((2,6-xylylcarbamoyl)methyl) ammonium benzoate, is the bitterest compound known.

The bitterest compound known Bitrex is used as an alcohol denaturant and flavor in pharmaceuticals. The process adds a small amount of a denaturant to the alcohol to make it taste bad, thus creating alcohol that is not suitable for drinking, but is otherwise similar for other purposes.

Bitrex is also available under the trade name Bitrex, which is a token of the words pain and rex for the king. Bitrex is a salt compound with an inert anion such as benzoate or saccharide.

Some automotive products, such as antifreeze and windshield washer fluids, contain Bitrex to prevent accidental ingestion, which could be harmful. Certain paints and coatings may include Bitrex to discourage consumption, which could be toxic.

Bitrex also applies to outdoor cables and wires to prevent rodents from chewing on parts and equipment. Bitrex is a deterrent agent added to various pesticides, plant food sticks, and rodenticides to suppress swallowing, especially when young children come into contact with these toxic substances.

Chemical Name: Denatonium benzoate Chemical Formula: C28H34N2O3 Molecular Weight: Approximately 442.6 g/mol Appearance: White, crystalline powder Odor: Odorless or faintly aromatic Taste: Extremely bitter (one of the most bitter substances known)

In some cases, Bitrex is used in medications to deter misuse or accidental ingestion. Bitrex can act as a bronchodilator by activating bitter taste receptors in the airway smooth muscle.

Cleanup Methods: Sweep up and dispose of the material according to local regulations. Clean the area with water and soap.

This ensures compatibility, stability and optimum Bitrex concentration to affect a bitter taste in the formulated product. Bitrex is currently known as the world's most painful ingredient.

Certification: The production process and the final product must comply with relevant regulations and standards (e.g., FDA, REACH, etc.).

Bitrex is non-toxic and is not absorbed significantly through the skin, making it safe for use in a wide range of consumer products. The use of Bitrex is subject to regulations in many countries.