As with other drugs there are no guarantees that cytotoxic drugs will work for you. On the other hand it isn't certain that serious negative effects will occur if you try these drugs. For severe cases of arthritis many experts agree that when properly used the risk of side effects from the drugs may be less than the risk to your health from the disease itself. Talk to your doctor about the side effects and whether the benefits of the medicine outweigh the risks.

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Azathioprine (Imuran) is usually given in pill form (2-3 tablets daily) or by injection. The dose may be lowered after the desired response is obtained.

Methotrexate (Rheumatrex) is usually given in pill form and sometimes by weekly injections. This drug can cause additional side effects such as liver scarring (cirrhosis) and a lung problem similar to pneumonia which causes shortness of breath cough and a fever.

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The Arthritis Foundation and the University of Washington Department of Orthopedics do not endorse any brand name or generic name medication listed here. Portions of the information presented here are adapted from the USP DI copyright 1990 the United States Pharmacopeial Convention Inc. (USP). Permission granted.

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Cyclophosphamide (Cytoxan) is usually given in pill form or intravenously according to a prescribed schedule. It is probably the strongest cytotoxic drug. It may cause additional side effects such as cystitis (inflammation of the bladder marked by blood in the urine and painful urination) as well as bladder cancer.

If cytotoxic drugs are recommended for you be sure to consult a doctor who has experience using these drugs. When considering treatment with cytotoxic drugs you your doctor and your family will want to consider factors such as:

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Some of this material may also be available in an Arthritis Foundation brochure. Contact the Washington/Alaska Chapter Helpline: (800) 542-0295. If dialing from outside of WA and AK contact the National Helpline: (800) 283-7800.

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Risk of infection Stay away from adults and children who have contagious illnesses such as colds the flu or chickenpox. Do NOT have any immunizations without checking with your doctor because they could lead to infection. Report any sign of an infection to your doctor right away. Loss of appetite Plan meals when you're not feeling nauseous. Try eating small more frequent meals. Ask your doctor if you can take the medicine at bedtime to reduce this side effect. Mouth sores Contact your doctor if these develop. Use a soft-bristled toothbrush. Use salt water or peroxide as a mouth wash. Eat soft non-spicy foods of medium to cold temperature. If the pain doesn't go away ask your doctor about using a topical pain reliever before meals. Easy bruising or bleeding This could be a sign of serious problems so you should contact your doctor right away.

The most important thing you can do to treat and help avoid some side effects is to have regular checkups. Here are some other things you can do to handle the following side effects:

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Cytotoxic drugs are very powerful medicines. They work by affecting the growth and action of some cells that cause the joint pain,  swelling,  warmth and damage of arthritis.

Cytotoxicity

Cytotoxic drugs can be used to treat many forms of arthritis including juvenile rheumatoid arthritis, psoriatic arthritis, rheumatoid arthritis and systemic lupus erythematosus as well as conditions such as steroid-resistant polymyositispolymyositisor dermatomyositis,  Wegener's granulomatosis polyarteritis or some forms of vasculitis.

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Cytotoxic drugs work over a long period of time. You may not notice much effect from the drugs for the first several weeks or months of treatment.

Other side effects may occur with these drugs. If you have any of these side effects or other problems not listed here check with your doctor or pharmacist:

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This information does not cover all generic and brand names possible uses actions precautions side effects or interactions of cytotoxic drugs. It should not replace the advice and guidance given by your doctor. If you have questions about these or other medications contact your doctor or pharmacist.

While these side effects don't happen very often you should still be aware of them. Some of them are signs of serious problems which should be treated right away.