The Department of Transportation (DOT) specifies that when 2,4,6-trinitrotoluene is shipped, it must be wet with at least 10% water (by weight) and it must be clearly labeled as a flammable solid.

For more information, contact: Agency for Toxic Substances and Disease Registry Office of Innovation and Analytics, Toxicology Section 4770 Buford Highway Chamblee, GA 30341-3717 Phone: 1-800-CDC-INFO 888-232-6348 (TTY) Email: Contact CDC-INFO

2,4,6-Trinitrotoluene is a yellow, odorless solid that does not occur naturally in the environment. It is commonly known as TNT and is an explosive used in military shells, bombs, and grenades, in industrial uses, and in underwater blasting.

This fact sheet answers the most frequently asked health questions about 2,4,6-trinitrotoluene (TNT). For more information, you may call the ATSDR Information Center at 1-800-232-4636. This fact sheet is one in a series of summaries about hazardous substances and their health effects. It is important you understand this information because this substance may harm you. The effects of exposure to any hazardous substance depend on the dose, the duration, how you are exposed, personal traits and habits, and whether other chemicals are present.

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The Occupational Safety and Health Administration (OSHA) set a maximum level of 1.5 milligrams of 2,4,6-trinitrotoluene per cubic meter of workplace air (1.5 mg/m3) for an 8-hour workday for a 40-hour workweek.

A simpler, but less specific test of 2,4,6-trinitrotoluene exposure is a change in the color of urine to amber or deep red due to the presence of its breakdown products. However, none of these tests can predict whether a person will experience any health effects.

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Workers involved in the production of explosives who were exposed to high concentrations of 2,4,6-trinitrotoluene in workplace air experienced several harmful health effects, including anemia and abnormal liver function.

The National Institute for Occupational Safety and Health (NIOSH) and the American Conference of Governmental Industrial Hygienists (ACGIH) recommend an exposure limit of 0.5 mg/m3 in workplace air for a 40-hour workweek.

Other effects in humans include skin irritation after prolonged skin contact, and cataract development after long-term (365 days or longer) exposure.

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It is not known whether 2,4,6-trinitrotoluene can cause birth defects in humans. However, male animals treated with high doses of 2,4,6-trinitrotoluene have developed serious reproductive system effects.

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Laboratory tests can detect 2,4,6-trinitrotoluene or its breakdown products in blood or urine. Detection of its breakdown products in urine is a clear indication of exposure. This test isn't available at most doctors' offices, but can be done at special laboratories that have the right equipment.

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Similar blood and liver effects, as well as spleen enlargement and other harmful effects on the immune system, have been observed in animals that ate or breathed 2,4,6-trinitrotoluene.

If you have questions or concerns, please contact your community or state health or environmental quality department or:

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Agency for Toxic Substances and Disease Registry (ATSDR). 1995. Toxicological Profile for 2,4,6-trinitrotoluene (TNT). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.

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The EPA has determined that 2,4,6-trinitrotoluene is a possible human carcinogen. This assessment was based on a study in which rats that ate 2,4,6-trinitrotoluene for long periods developed tumors of the urinary bladder.

ATSDR can also tell you the location of occupational and environmental health clinics. These clinics specialize in recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances.

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Exposure to 2,4,6-trinitrotoluene occurs through eating, drinking, touching, or inhaling contaminated soil, water, food, or air. Health effects reported in people exposed to 2,4,6-trinitrotoluene include anemia, abnormal liver function, skin irritation, and cataracts. This substance has been found in at least 20 of the 1,430 National Priorities List sites identified by the Environmental Protection Agency.

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