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Surgical interventions are advocated by many authors in cases of scrolled, nonplanar, extensive and visually impairing DMDs, mostly to hasten visual rehabilitation and prevent fibrosis of DM. Also, all persistent DMD cases with conservative therapy should undergo surgical intervention.

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There are many DMD classifications by several authors. In one of them, Kumar et al proposed an AS-OCT-based HELP algorithm (stands for height (measured as distance between detached DM and corneal stroma), extent of DM in the cornea (central, para central and peripheral cornea), length of the detachment and pupil (position of DMD to pupil)) to aid in the management of different types of DMD:[7]

It’s the surgical reattachment of the detached DM with an injection of air and/or isoexpansile gases like perfluoropropane (C3F8, 12 – 14%) and sulfur hexafluoride (SF6, 15 – 20%). Gases reduce the need for reinjection due to their longer reabsorption time (SF6: 2 weeks and C3F8: 6 weeks). It has become the gold standard treatment for DMD management mainly due to its ease of execution and subsequent good outcomes. The technique generally involves filling a syringe with the desired air/gas and injecting it with a 27 – 30G needle. Generally, a complete gas-filled chamber is maintained for 15 – 20 minutes and then release one-third of the bubble to avoid a postoperative pupillary block. It is advised to do an inferior peripheral iridectomy and for the patient to maintain a supine position after the procedure. Other surgeons prefer to use cycloplegic drops and prophylactic peripheral iridotomy to prevent high intraocular pressure.

The volume of a cylinder follows the same logic as the prism.  The only difference is a change in the base, which is now a circle. Then the volume of the cylinder is

Decrementation

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There are many reports on the spontaneous resolution of corneal edema, either by reattachment of the DM or migration of nearby endothelial cells.

Decementsynonyms

DMD normally occurs as aqueous enters the pre-descemetic space along a tear in Descemet’s membrane (DM). The main cause of DMD is iatrogenic, after intraocular surgery, followed by ocular trauma and in rare, predisposed cases, spontaneously.

Transcorneal interrupted suturing using a 10/00 monofilament Nylon suture has been described, frequently associated with intracameral injection of air/gas.

The diagnosis of DMD is mostly clinical, based on history and slit lamp examination, especially if the cornea is clear. However, if there is significant corneal edema, imaging tools such as anterior segment optical coherence tomography (AS-OCT) are fundamental for the diagnosis.

To find the volume of a cone, we follow the same principle as for the cylinder.  So we use the same method, but the base is now circular. Then we have

In cases where severe corneal edema is present, other diagnostic tests can aid the diagnosis. The most used and accurate exam for the diagnosis of DMDs is the anterior segment optical coherence tomography (AS-OCT). AS-OCT is a quick, non-contact modality that can determine the exact location, configuration, and extent of the DMD, not only confirming the diagnosis but also guiding the treatment method and outcomes.

Reattachment outcomes vary from 90% – 100% of cases. Reinjection is necessary for a small percentage of cases (4 -7%) and should be attempted before more complex procedures like endothelial keratoplasty.[8][9][10]

Patient-related risk factors include age over 65 years, preexisting endothelial diseases like Fuchs dystrophy, and intrinsic Descemet stromal interface abnormalities. Previous history of chemical injury, bleeding from corneal neovascularization and dense cataracts. Intraoperative risk factors include use of blunt instruments for incisions, tight or small incisions as compared to the size of the phacoemulsification probe or poorly performed clear corneal incisions (small, oblique, or ragged), inadvertent insertion of surgical instruments between stroma and DM, entry into the anterior chamber in a soft globe, and prolonged surgical time. Postoperative risk factors include genetic causes of weak adhesion between DM and posterior corneal stroma when DMD presents weeks after uncomplicated cataract surgery.[6][3]

If we take the proportion of the areas of the base of our box and the gifts we can find how many cubes we can fit in the base area of the box:

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The management of DMD is on a case-by-case basis. Early decision on the therapeutic approach is the most important factor to achieve the best visual outcome. Other important decision-making parameters include the site, extent, and height of the DMD along with the presence of any scrolled edges.[6]

Patients with DMD present with poor visual improvement after cataract surgery or sudden vision loss in cases with delayed presentation or after keratoplasty and glaucoma surgery. Foreign body sensation can be present due to irregular corneal epithelium.

Cataract surgery is where DMD happens the most, especially after extracapsular cataract extraction and phacoemulsification (with an incidence of 2.5% and 0.5% respectively).[1] DMD has also been reported in other surgeries such as keratoplasty, pars plana vitrectomy, iridectomy, trabeculectomy, laser capsulotomy, laser sclerostomy and viscocanalostomy.[1][2] [3]Chemical injuries (especially alkaline) and blunt trauma (e.g., birth forceps injury) can also cause DMDs. In chemical injuries, the presence of limbal ischemia, iris synechiae and exudations in the anterior chamber seem to play a role in DMD[4]. Spontaneous DMD occurs in acute hydrops associated with ectatic corneal disorders or as a delayed presentation after uncomplicated surgery in predisposed patients.[5][6]

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Decreasement Synonym

The diagnosis of DMD is mostly clinical. If the overlying cornea is clear, a slit-lamp examination can quickly identify DMDs. Gonioscopy may also be used for localized peripheral DMDs.

The most common complication after Descemetopexy is persistent DMD, followed by raised intraocular pressure and pupillary block glaucoma (up to 13% of cases),[7][11] especially when using C3F8 gas.[12] Other less common complications of Descemetopexy include uveitis[10] and Urrets-Zavalia syndrome due to iris ischemia.[13]

Great for curious kids! Made of durable plastic. Measures: 2" W x 5 1/2" L. Box of 24 in assorted colours.

Decementexamples

As we already saw, the volume of a prism is the area of the base times the height of the prism. The volume of the pyramid has the same base area and height as the prism, but with less volume than the prism. The volume of the pyramid is one third the volume of the prism.

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The box shown is 10 cm wide, 4 cm long, and 6 cm high. If you have gifts that are cubes, with a length of 1 cm, how many cubes will fit inside the box? What is the volume of the box?

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Volume is the quantity of space, calculated in cubic units, which a body occupies. The following lesson will explain the general formulas used to find the volume of the most frequently used solid figures: prisms, cylinders, pyramids, and cones.

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Sharma et al suggested an AS-OCT-based algorithm for the management of persistent DMD after intraocular surgery. All the planar DMDs involving the superior half of the cornea should undergo intracameral injection of air. The use of gas was recommended for DMD involving the inferior half of the cornea and superior DMD with scrolled edges.[2]

DMD is usually seen as a translucent membrane in the anterior chamber, at the site of corneal incision or DM perforation. The hallmark sign of DMD is localized or diffuse corneal edema over the DMD that, with time, can become persistent. Other signs include DM folds and microcystic epithelial edema or bullae. Extensive and central DMDs may create a typical “double anterior chamber” appearance. Any case with severe post operative corneal edema should be investigated to rule out DMD so that timely intervention can be performed.[6]

The examination should consist of an ophthalmic work-up including visual acuity, slit-lamp examination, gonioscopy and other diagnostic tests like UBM and AS-OCT.

Decementdefinition

Manual repositioning of the DM is now considered an obsolete procedure. Various types of descemetotomy have also been reported alone or followed by intracameral injection of air/gas. Keratoplasty is the last treatment option for recalcitrant DMD cases. Descemet Stripping Endothelial Keratoplasty is the preferred technique for the management of these persistent cases.

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The prognosis of most patients with DMD is good, especially in small, peripheral cases. Prompt treatment should be advised for cases where there is a higher probability of persistent edema like large central DMDs.

So we can fit 40 of the gift boxes per base area, but we need to find out how many gifts will fit in the whole box. Five more layers of cubes can be placed on top of the base layer to fill the box. Now that the box contains 6 layers of gifts, with 40 gifts on each layer, the box will be filled by a total of 240 gifts. For this example, we used the method for finding the volume of a prism to find how many 1 cm3 gift boxes can fit.

Descemet membrane detachment (DMD) is a disease of the posterior cornea that mostly occurs as a complication of intraocular surgery but also due to ocular trauma and even spontaneously. After a DMD, the overlying corneal stroma and epithelium swell, and visual acuity can be permanently affected. Although most DMD resolve spontaneously after surgery, descemetopexy is the gold standard for the management of persistent DMD.

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Conservative treatment includes topical steroids and hyperosmotic agents. Steroids help to control inflammation and reduce the risk of DM fibrosis. Hypertonic agents help to clear corneal edema by dehydrating stroma.

The natural history of DMD is still uncertain and unpredictable. Although most DMDs are small and self-sealing with no corresponding visual complaints, some can present with severe corneal edema and vision loss if the detachment is extensive. In this case, spontaneous resolution is unlikely and if not treated in time, can lead to corneal decompensation and opacification.

Most patients will have a history of recent intraocular surgery and since DMDs are not a rare complication, it’s important to discuss predisposing factors with the patient before surgery.

Surgical repair with intracameral injection of viscosurgical devices or perfluorocarbons has been reported in isolated case reports with some success but due to intraocular pressure spikes with viscoelastic and possible endothelial toxicity with perfluorocarbons, care should be taken.