Opticalmicroscope

About a decade ago, Columbia University scientists proposed that a different type of UVC light, known as far-UVC light, would be just as efficient at destroying bacteria and viruses but without the safety concerns of conventional germicidal UVC.

The study suggests that far-UVC light from lamps installed in the ceiling could be a highly effective passive technology for reducing person-to-person transmission of airborne-mediated diseases such as COVID and influenza indoors, and lowering the risk of the next pandemic.

A new type of ultraviolet light that may be safe for people took less than five minutes to reduce the level of indoor airborne microbes by more than 98%, a joint study by scientists at Columbia University Vagelos College of Physicians and Surgeons and in the U.K. has found. Even as microbes continued to be sprayed into the room, the level remained very low as long as the lights were on.

Leica objective

“Far-UVC light is simple to install, it’s inexpensive, it doesn’t need people to change their behavior, and evidence from multiple studies suggests it may be a safe way to prevent the transmission of any virus, including the COVID virus and its variants, as well as influenza and also any potential future pandemic viruses,” Brenner says.

Avantier, a premier manufacturer of high performance microscope objective lenses, produces a wide range of quality microscope objectives for diverse applications, including research, industry, forensics, and medical diagnostics. We carry many types of objectives in stock, including apochromatic, achromatic,  and semi-apochromatic. We can also produce custom objectives tailored to perform optimally within your specific spectral range, ensuring the highest level of imaging precision for your application.

The lamps inactivated more than 98% of the airborne microbes in just five minutes. The low level of viable microbes was maintained over time, even though microbes continued to be sprayed into the room.

“Previous studies have shown that far-UVC light can kill the COVID virus, other human coronaviruses, influenza, and drug-resistant bacteria,” Brenner says. “What’s particularly attractive about far-UVC technology as a practical method of preventing indoor disease transmission is that it will be equally good at inactivating all future COVID variants, as well as new infectious viruses that have yet to emerge, while retaining efficacy against ‘old fashioned’ viruses like influenza and measles.”

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Confocal microscopy

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Disinfecting indoor air with far-UVC light is a new approach to safely and efficiently destroy airborne viruses in occupied spaces, including the viruses that cause COVID and influenza.

The authors are Ewan Eadie (Ninewells Hospital, Dundee, Scotland), Waseem Hiwar (University of Leeds, England), Louise Fletcher (University of Leeds), Emma Tidswell (University of Leeds), Paul O’Mahoney (University of Dundee), Manuela Buonanno (Columbia University), David Welch (Columbia University), Catherine Adamson (St. Andrews University, Scotland), David Brenner (Columbia University), Catherine Noakes (University of Leeds), and Kenneth Woods (University of St. Andrews).

In the current study, scientists at the University of St. Andrews, University of Dundee, University of Leeds, and Columbia University tested the efficacy of far-UVC light in a large room-sized chamber with the same ventilation rate as a typical home or office (about three air changes per hour).

While a microscope comprises numerous parts, the objective lens arguably serves as its cornerstone. The resolving power, total magnification, and ultimate image quality of a microscope hinge largely on the chosen objective lens.

What does the objective lens do on amicroscope

During the experiment, a sprayer continuously emitted an aerosol mist of S. aureus bacteria into the room. (This microbe was chosen because it is slightly less sensitive to far-UVC light than coronaviruses, providing the researchers with an appropriately conservative model.) When the concentration of microbes in the room stabilized, the researchers turned on commercially available overhead far-UVC lamps.

Zeiss objective

The study, titled “Far-UVC (222 nm) efficiently inactivates an airborne pathogen in a room-sized chamber,” was published in Scientific Reports on March 23.

Avantier continues to redefine precision microscopy with its cutting-edge NIR, NUV, and UV infinity corrected objectives. Engineered for accuracy and clarity, these objectives elevate research and analysis across near-infrared (NIR), near-ultraviolet (NUV), and ultraviolet (UV) spectra. With advanced optical coatings, aberration correction, and infinity-corrected designs, researchers can explore samples with unmatched clarity and fidelity. These objectives are pivotal for applications ranging from material science to life sciences, enabling scientists to delve deeper into the microscopic world with confidence. Avantier offers a wide variety of microscopes, each equipped  with  multiple objective lenses that can be rotated to view specimens at varying magnification powers. Demonstrating its commitment to excellence, Avantier delivers tools that empower scientific discovery and innovation.

What is the purpose of the objective lens in a lightmicroscope

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A new study from David Brenner's lab at Columbia University's Center for Radiological Research found that far-UVC light does not cause damage in a 3-dimensional model of human skin. In another study from Brenner's team, hairless mice exposed to far-UVC light for 8 hours a day over 15 months had no signs of skin damage. The findings suggest that far-UVC light may be safe for use in occupied indoor settings.

In the past decade, many studies have also shown that far-UVC is efficient at destroying airborne bacteria and viruses, which are much smaller than human cells. But until now these studies had only been conducted in small experimental chambers, not in full-sized rooms mimicking real-world conditions.

Finally, because of the way ultraviolet light kills microbes, viruses and bacteria cannot develop resistance as they do with vaccines and drug treatments.

Scientists have known for decades that a type of ultraviolet light known as UVC light rapidly kills microbes, including bacteria and viruses. But conventional germicidal UVC light cannot be used directly to destroy airborne viruses in occupied indoor spaces because it is a potential health hazard to the skin and eyes.

Objectives are designed to magnify an object by a specific factor, ranging from 4x (a scanning objective) to 40x (a high-power objective), and even up to 100x for an oil immersion lens. To maximize flexibility, microscopes are often equipped with up to four objectives mounted on a rotating nosepiece or turret. In the case of an infinity-corrected objective lens, the magnification is calculated by dividing the reference focal length by the objective’s focal length.

“Our trials produced spectacular results, far exceeding what is possible with ventilation alone,” says Kenneth Wood, PhD, lecturer in the School of Physics and Astronomy at the University of St. Andrews and senior author of the study. “In terms of preventing airborne disease transmission, far-UVC lights could make indoor places as safe as being outside on the golf course on a breezy day at St. Andrews.”

Lumenmicroscope

David J. Brenner and co-inventors have been granted a U.S. patent titled "Apparatus, method and system for selectively affecting and/or killing a virus" (US1078019B2). Columbia University has licensed aspects of filtered UV light technology to USHIO Inc. Other disclosures are noted in the paper.

The efficacy of different approaches to reducing indoor virus levels is usually measured in terms of equivalent air changes per hour. In this study, far-UVC lamps produced the equivalent of 184 equivalent air exchanges per hour. This surpasses any other approach to disinfecting occupied indoor spaces, where five to 20 equivalent air changes per hour is the best that can be achieved practically.

Objective lensmicroscope

Columbia Vagelos College of Physicians and Surgeons is dedicated to developing the next generation of leaders in medicine

Far-UVC light has a shorter wavelength than conventional germicidal UVC, and several studies from around the world suggest it is unable to penetrate into skin cells or eye cells.

The microscope’s total magnification can be calculated by multiplying the magnification power of the eyepiece by that of the objective lens. For example, viewing an object through a 10x eyepiece and a 4x objective results in a 40x magnified image.

“Far-UVC rapidly reduces the amount of active microbes in the indoor air to almost zero, making indoor air essentially as safe as outdoor air,” says David Brenner, PhD, director of the Center for Radiological Research at Columbia University Vagelos College of Physicians and Surgeons and co-author of the study. “Using this technology in locations where people gather together indoors could prevent the next potential pandemic.”

A microscope objective lens produces a real, magnified image of an object placed within its field of view. The image is then further magnified by the ocular lens (eyepiece) before being observed. At Avantier, we offer in-stock microscope objective lenses, readily available for immediate use in a variety of applications. For unique or specialized requirements, we offer custom solutions for multiple objective lenses.