Fluorescence imaging is the visualization of fluorescent dyes or proteins as labels for molecular processes or structures. It enables a wide range of experimental observations including the location and dynamics of gene expression, protein expression and molecular interactions in cells and tissues.

Newport

A study optimizes a system effectively inducing gene expression by infrared laser heating and characterizes the induction profile of single cells in the different conditions through quantitative imaging analysis in the moss Physcomitrium patens.

Studying membrane contact sites at high spatiotemporal resolution is still challenging. Here, authors introduce a series of dynamic chemogenetic reporters to visualize these subcellular regions and study the associated calcium signals.

Opticalcomponents

A computational mesoscale microscope offers large-scale volumetric imaging of intravital dynamics with cellular resolution.

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OpticaldovetailRail

Voltage imaging, a promising technique for directly recording neuronal activity, faces barriers to broad application due to current limitations in compatible imaging modalities. Our team introduces an advanced confocal light field microscopy method enabling high-throughput, rapid and low-noise 3D voltage imaging in awake mice.

Thorlabs Rails

Thorlabs

Fenton et al. show that FMRP granules dock at the mitochondrial midzone in a Rab7-dependent manner in axons and dendrites, where they promote local MFF synthesis and fission at the mitochondrial midzone.

We developed ‘imaging-based chromatin and epigenetic age’ (ImAge), a technique that captures intrinsic age-related trajectories of the spatial organization of chromatin and epigenetic marks in single nuclei. We propose that ImAge represents a first-in-class imaging-based biomarker of aging with single-cell resolution.

Okra505 is a new green-fluorescent photostable RNA aptamer that enables mRNA dynamics to be visualized in live cellular processes, outperforming established fluorescent RNA visualization tools.

ONIX is a data acquisition system for recording freely behaving mice. It can accommodate a variety of recording technologies, while maintaining minimal impact on animal behavior.

Long-term tracking of learned actions in mouse motor cortex shows that learned actions are retained with their context, and learning new tasks creates new memories, which do not overwrite or modify existing representations.