3mmHex Socket

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3mmHexkeydimensions

Raman flow cytometry offers chemically sensitive, label-free measurement of cells and particles; however, the technique suffers from low cell throughput due to the weak Raman signal. Here, we demonstrate the use of time-delay integration to achieve Raman flow cytometry combined with dual-sided line illumination. The use of line illumination from both sides of the cell flow capillary kept the cell stream in the detection area by balancing optical force from the illumination lines. The time-delay integration allowed accumulation of Raman signals from flowing cells without sacrificing the spectrum readout rate. With the developed system, we achieved Raman flow cytometry at throughputs of 32 and 75 events per second for cell and particle detection, respectively. We applied the technique for analyzing lipid uptake in HepG2 cells and degranulation in bone marrow-derived murine mast cells.

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WARNING: This product can expose you to chemicals ​(Rust Prevention Oil) ​which are known to the State of California to cause cancer​. ​Always wash your hands after unpacking the product for first use and use in a well ventilated area. Dispose of packaging bags thoughtfully.

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MLindley, TK, and KF have patent application related to this work (PCT/JP2024/003220). K.F. is a co-founder and the chief technology officer (CTO) of Millde Co., Ltd. The other authors have no competing of interests.