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Einfallendes Licht wird durch einen 50:50-Strahlteiler in zwei verschiedene Lichtstrahlen derselben Intensität und fester relativer Phase aufgeteilt und an einem zweiten Strahlteiler wieder überlagert. Da das Licht vom Eingang aus, jeden der beiden Ausgänge auf zwei verschiedenen Wegen erreichen kann, kommt es zur Interferenz zwischen den Lichtstrahlen, welche den „oberen“ bzw. den „unteren“ Weg genommen haben, wodurch die Intensität in beiden Ausgängen von der optischen Weglängendifferenz zwischen den beiden Wegen abhängt.

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da ⟨ a i n , 1 † a i n , 2 ⟩ = 0 {\displaystyle \langle a_{\mathrm {in} ,1}^{\dagger }a_{\mathrm {in} ,2}\rangle =0} .

Are AI-based at-the-patient devices that enable primary care physicians to identify cancer a paradigm shift in medicine? Their effect on the practice of medicine could be seen as just part of a continuum of change of the type previously brought by consult room/bedside/instant lab molecular-based diagnostic tests in various disciplines. Whether you see AI-based approaches of this type as a revolution or an evolution - they certainly bring interesting questions in regulation and implementation. Not least if which is how is bias and skin colour applicability addressed - so it is worth reading our article with Harvard Medical School Kaushik Venkatesh Kushal Kadakia Stephen Gilbert https://lnkd.in/eAd5NHNJ Else Kröner Fresenius Center for Digital Health Nature Portfolio

Sagnac effect

Die Ursache der geänderten Weglängendifferenz kann eine Bewegung der Spiegel relativ zum Strahlteiler oder ein sich ändernder Brechungsindex n > 1 {\displaystyle n>1} in einen der Wege sein.

Another huge milestone for RefluxStop™ - New real-world data published in Nature Scientific Reports further demonstrating its excellent safety and patient outcomes in a widely underserved GERD patient population in a real-world setting! Read more about this groundbreaking research: https://lnkd.in/gup38rRB Many congratulations to Professor Sebastian F. Schoppmann at the University of Vienna, Austria, and Mr. Nick Boyle at King Edward VII Hospital in London, UK, for their outstanding work! Implantica press release- https://lnkd.in/gNWsfxH8 Prof. Dr. Sebastian Schoppmann of the Medical University of Vienna says, “It’s exciting to conduct the first real-world multicenter study assessing the safety and efficacy of the RefluxStop procedure. We found patients treated with RefluxStop experienced substantial improvements in quality of life and reflux symptoms with minimal safety issues despite all having ineffective esophageal motility. IEM is a well-known group of patients without any effective treatment options.” He adds, “Given RefluxStop’s great promising early results showing significant improvement in patient outcomes in GERD, we are now planning additional studies to validate our findings further and hopefully establish this as an effective treatment option to help the widely underserved GERD patient population.” #RefluxStop #GERD #Innovation #Implantica

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Endometriosis is more than a medical condition; it’s a sneaky thief that can rob some women of motherhood aspirations, often leaving them to face the devastating experience of infertility. That’s why early detection and effective treatments are so important. A recent study published in the 𝘐𝘯𝘵𝘦𝘳𝘯𝘢𝘵𝘪𝘰𝘯𝘢𝘭 𝘑𝘰𝘶𝘳𝘯𝘢𝘭 𝘰𝘧 𝘔𝘰𝘭𝘦𝘤𝘶𝘭𝘢𝘳 𝘚𝘤𝘪𝘦𝘯𝘤𝘦𝘴, entitled, “The Cellular Respiration of Endometrial Biopsies from Patients with Various Forms of Endometriosis,” indicates the key to targeted therapies may lie in the metabolic characteristics of endometriosis. The study showed there is a difference in mitochondrial respiratory rates, depending upon the complexity and subtype of endometriosis. The value of this study for ENDOSURE, INC. is that the ENDOSURE TEST’s activity index is most likely a measure of this mitochondrial respiratory activity. When asked about this, Dr. Mark Noar, inventor of the ENDOSURE TEST, said: “This paper represents a critical piece of the puzzle of this -- until now -- difficult to diagnose disease. The ENDOSURE TEST result activity level appears to mirror the activity level of the disease and will change in proportion to the disease activity. After surgical excision of disease, we see the disease activity level normalize. Similarly, we also see the test result level decrease after the introduction of symptom controlling medication. This suggests that the ENDOSURE TEST allows for easy-to-implement, post treatment monitoring...something completely missing in today’s management of endometriosis.” The ENDOSURE TEST is the only non-invasive, 30-minute, 99+% accurate diagnostic tool that can diagnose the presence of endometriosis regardless of the disease stage (I, II, III, or IV). This powerful tool empowers clinicians to gain deeper insights into endometriosis and develop more effective, targeted therapies, restoring hope to every woman affected by this debilitating disease. 𝐏𝐥𝐞𝐚𝐬𝐞 𝐭𝐞𝐥𝐥 𝐮𝐬 𝐰𝐡𝐚𝐭 𝐢𝐦𝐩𝐚𝐜𝐭 𝐲𝐨𝐮 𝐭𝐡𝐢𝐧𝐤 𝐭𝐡𝐞 𝐄𝐍𝐃𝐎𝐒𝐔𝐑𝐄 𝐓𝐄𝐒𝐓 𝐦𝐚𝐲 𝐡𝐚𝐯𝐞 𝐨𝐧 𝐭𝐡𝐞 𝐟𝐮𝐭𝐮𝐫𝐞 𝐨𝐟 𝐞𝐧𝐝𝐨𝐦𝐞𝐭𝐫𝐢𝐨𝐬𝐢𝐬 𝐝𝐢𝐚𝐠𝐧𝐨𝐬𝐢𝐬 𝐚𝐧𝐝 𝐭𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭? #Endometriosis #Femtech #WomensHealth #Medtech

Das Mach-Zehnder-Interferometer ist eine Weiterentwicklung des Jamin-Interferometers. Es wurde 1891/1892 unabhängig voneinander vom Österreicher Ludwig Mach (Sohn von Ernst Mach) und seinem Schweizer Kollegen Ludwig Zehnder entwickelt.

MZI

Real world is always complex but it gives the 'external validation' of any technology. Here is another real-world study of RefluxStop from an academic hospital in Austria.

Beam splitter

In der photonischen Nachrichtentechnik werden integrierte Mach-Zehnder-Interferometer zum wellenlängenabhängigen Demultiplexing eingesetzt.[4]

Wird jetzt die optische Weglängendifferenz verändert, dann lässt sich die entstehende Phasendifferenz Δ Φ {\displaystyle \Delta \Phi } aus den Intensitäten I 3 , I 4 {\displaystyle I_{3},I_{4}} in den beiden Ausgängen bestimmen. Dabei gilt der Zusammenhang:

It’s been a little while… Stopped by to bring some insights on this research I found it interesting 🤨 This Illuminates the Impact of Atrial Functional Mitral Regurgitation Severity on Patient Outcomes 🚨 A recent multicenter study spanning 26 centers across Japan has made significant strides in understanding the impact of atrial functional mitral regurgitation (AFMR) on patient outcomes. This study, the first of its kind, systematically analyzed 1,007 patients with moderate to severe AFMR, revealing crucial insights into how the severity of this condition influences the risk of adverse events. Key Findings: • Severity Matters: Patients with severe AFMR exhibited a significantly higher risk of death, heart failure hospitalization, and mitral valve interventions. • Quantitative Thresholds: Effective regurgitant orifice area (EROA) ≥0.30, regurgitant volume ≥60 mL, and regurgitant fraction ≥50% were identified as critical markers that predict higher event risks. • Consistent Risk Across Groups: Despite similar age, sex, and left ventricular ejection fractions, patients with severe AFMR faced worse outcomes, emphasizing the importance of severity assessment in clinical practice. Implications for Healthcare: This study underscores the necessity of both qualitative and quantitative assessments in managing AFMR. By establishing clear thresholds for intervention, healthcare professionals can better plan treatment strategies, potentially improving the prognosis for thousands of patients suffering from this condition. 👉 What This Means for Cardiologists: The findings from this study provide a valuable framework for evaluating AFMR severity and tailoring intervention approaches more effectively. 🔍 The Way Forward: As we continue to explore the nuances of AFMR, this research lights the path for future studies and enhances our understanding, enabling healthcare providers to make informed decisions that improve patient care outcomes. 💡 Interested in the full details of this pivotal study? In the comments section #medicalresearch #Cardiology #afib

Ein Mach-Zehnder-Interferometer kann sowohl zur Modulation von Licht durch gezielte Phasenmodulation in einem Arm des Interferometers als auch zur Messung von Phasenverschiebungen eingesetzt werden.

In an ever-evolving landscape of healthcare, early diagnosis is crucial for effective treatment plans and improved patient outcomes. This is why I’m pleased to share that Novartis Canada has partnered with Clarius Mobile Health to improve accessibility to medical imaging in Canada. This partnership provides rheumatologists with access to an AI-enabled portable ultrasound device and a comprehensive training program, to help decrease the time to detection for patients with psoriatic arthritis (PsA). With more than half of patients with PsA waiting two or more years for a diagnosis, I'm eager to see how our efforts will positively impact the lives of people living with the disease. I recently had the opportunity to sit down with The Globe and Mail to discuss this partnership and the relationship between healthcare and technology. Read more below. #FutureOfHealthcare #ReimaginingMedicineTogether

Decoherence

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Selective ultrasound-guided nerve root block improves outcomes for discectomy in patients with cervical disc disease: a randomized, controlled, single-blinded study Study Results: Ultrasound-Guided Nerve Root Block for Cervical Disc Disease Key Findings: Ultrasound-guided selective nerve root block significantly improved pain intensity and neck disability index scores in patients with multilevel cervical disease. Patients in the study group showed a ≥50% reduction in pain scores and a VAS rating of ≤2 at weeks four, eight, and 12, indicating a successful surgical outcome. The study group demonstrated lower VAS pain scores and improved neck disability index compared to the control group. No significant adverse events were reported in the study group, and patients were highly satisfied with the procedure. Practical Solutions and Value: Ultrasound-guided selective nerve root block offers a safe, non-radiating, and reliable diagnostic tool to determine the appropriate level for operation in patients with multilevel cervical disease. This approach can help clinicians make informed decisions and improve surgical outcomes for patients undergoing selective anterior cervical discectomy and fusion. Integrating Clinical Trials into Medical Practice: Clinical trials play a crucial role in developing safe and effective treatments. Our AI-driven platform, DocSym, consolidates ICD-11 standards, clinical protocols, and research into an easily accessible knowledge base for clinicians. Streamlining operations in healthcare is essential, and our mobile apps support scheduling, monitoring treatments, and telemedicine, facilitating efficient patient care and digital service expansion. By leveraging AI, clinics can enhance workflows, improve patient outcomes, and reduce paper-based routines. Learn more about our solutions at aidevmd.com. https://lnkd.in/gy9TJ5qR #ClinicalTrials #AIinHealthcare #MedicalAI #HealthTech #DigitalHealth #PatientCareAI #AIResearch #MedicalInnovation #BioTech #AIforGood #HealthcareData #AIinMedicine #PharmaAI #ClinicalData #HealthAI #AIHealthSolutions #PrecisionMedicine #AIandHealth #ClinicalAnalytics #AIDiagnostics

wobei das Minuszeichen der Phasendifferenz zwischen Reflexion und Transmission Rechnung trägt.[3] Im zweiten Schritt propagieren die Felder a u {\displaystyle a_{u}} und a o {\displaystyle a_{o}} frei, wobei sie Phasen Φ u , Φ o {\displaystyle \Phi _{u},\Phi _{o}} aufsammeln, die von der jeweiligen optischen Weglänge der beiden Wege bestimmt werden.

🤝 We are honored to collaborate with Novartis Canada to enhance patient care and improve accessibility to medical imaging in Canada 🍁

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Ist die optische Weglänge für beide Wege gleich ( Δ Φ = 0 {\displaystyle \Delta \Phi =0} ) dann ist die Intensität im Ausgang 4 (nach oben) maximal (konstruktive Interferenz) und im Ausgang 3 (nach rechts) null (destruktive Interferenz). Dies ergibt sich aus den Reflexions- und Transmissionsprozessen an den beiden Strahlteilern. Auf dem Weg von 1 nach 4 kommt es entweder zu zwei Reflexionen, die jeweils einen Phasensprung von 180º bewirken, (oberer Weg) oder zu zwei Transmissionen (keine Phasensprünge), sodass die Phasendifferenz insgesamt 360º beträgt und die beiden Wege im Ausgang 4 konstruktiv interferieren. Dagegen ergibt sich für die beiden Wege von 1 nach 3 eine Phasendifferenz von 180º zwischen oberen und unterem Weg (und damit destruktive Interferenz), da es zwar auf jedem der beiden Wege zu einer Reflexion kommt, aber nur auf dem oberen Weg eine Reflexion am optisch dichteren Medium stattfindet, während am zweiten Strahlteiler an der Grenze zum optisch dünneren Medium reflektiert wird, was keinen Phasensprung zur Folge hat.[1]

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Im Folgenden ist nur die Phasendifferenz Δ Φ = Φ o − Φ u {\displaystyle \Delta \Phi =\Phi _{o}-\Phi _{u}} wichtig, und wir setzen Φ u = 0 {\displaystyle \Phi _{u}=0} . Im dritten Schritt transformiert der zweite Strahlteiler die Felder a u , a o {\displaystyle a_{u},a_{o}} in die zwei Output-Felder a o u t , 3 , a o u t , 4 {\displaystyle a_{\mathrm {out} ,3},a_{\mathrm {out} ,4}} gemäß:

All fiber mach zehnder interferometers for sensing applications

Im Formalismus der zweiten Quantisierung wird das Input-Feld durch einen bosonischen Operator a in {\displaystyle a_{\text{in}}} beschrieben.[2] Um die Erhaltung der Vertauschungsrelationen der bosonischen Kletteroperatoren (und die Unitarität der Zeitentwicklung) zu gewährleisten, muss nun auch das Feld a i n , 2 {\displaystyle a_{\mathrm {in} ,2}} im zweiten Eingang des Interferometers (von unten) betrachtet werden, selbst wenn dort kein Licht ins Interferometer eintritt (d. h., dort der Vakuumzustand des Feldes anliegt). Der Durchgang durch das Interferometer kann vereinfacht als eine Folge von drei Schritten (Streuprozessen) betrachtet werden: Im ersten Schritt wird das Input-Feld am ersten Strahlteiler gestreut und dadurch die Felder an den beiden Ausgängen das Strahlteilers, die als a o , a u {\displaystyle a_{o},a_{u}} bezeichnet werden, da sie zum oberen und unteren Weg durch das Interferometer gehören, in Überlagerungen der Input-Felder transformiert. Und zwar gilt:

🚀 Exciting News in Nephrostomy Devices Industry! 🚀 The nephrostomy devices market is projected to achieve an 8.3% CAGR from 2023 to 2032! 📈 This growth is fueled by the rising prevalence of kidney disorders and the increasing adoption of minimally invasive surgical procedures. 🏥🔧 Stay updated for the latest advancements in kidney health technology! 🌐🩺 #KidneyHealth #NephrostomyDevices #MedicalInnovation #HealthcareGrowth #MinimallyInvasive #HealthTech #FutureOfMedicine

The American College of Cardiology is proud to recognize cardiologists who are pioneering digital therapeutics in #India and advancing digital solutions to improve patient outcomes globally. Key Learnings: 1. Guideline directed medical therapy #GDMT can be achieved in the community with user friendly algorithmic prompts and culturally guided patient agency 2. Global medical systems which effectively increase access to technology can inform #digitalhealth and #AI implementation in resource-limited communities anywhere 3. Our global network of #cardiovascular #innovators can pressure test solutions and improve the collective efficacy worldwide of digital #healthtech and #collaborativeintelligence solutions Ed Fry Cathy Gates Neal Kovach, MBA Jennifer Bae Bryson Childress Dipti Itchhaporia, M.D., MACC, FAHA, FESC Tata Elxsi Tata Group Lupin Lupin Pharmaceuticals Lupin Digital Health W Health Ventures Bessemer Venture Partners United Nations Harvard Medical School Yale Alumni Association Read more at: https://lnkd.in/eCeacqfU

Spinal cord stimulation combined with exercise in patients diagnosed with persistent spinal pain syndrome. Study protocol for a randomized control trial Spinal Cord Stimulation and Exercise for Persistent Spinal Pain Syndrome Study Overview This study investigates how spinal cord stimulation (SCS) combined with exercise can help patients with persistent spinal pain syndrome (PSPS-T2). The goal is to see if this combination can reduce pain, improve quality of life, and decrease disability. Study Design We are conducting a double-blind randomized clinical trial. This means participants will be randomly assigned to either the treatment group or a control group without knowing which group they are in. The study follows strict guidelines to ensure reliability and has been registered at Clinicaltrial.gov. Participants We aim to recruit 52 participants, accounting for a possible 30% dropout rate. Each participant will attend two sessions per week for 8 weeks, totaling 16 sessions. Each session will last 60 minutes and will focus on safe exercises to avoid complications. Expected Outcomes The main outcomes we will measure include: Functionality Satisfaction Strength Psychosocial factors Quality of life Pain perception Importance of Clinical Trials Clinical trials are essential for developing safe and effective treatments. They help translate research findings into everyday medical practice. Practical Solutions for Healthcare Our AI-driven platform, DocSym, consolidates clinical standards and research into an easy-to-use resource for healthcare providers. This helps streamline operations and improve patient care. Enhancing Patient Care Our mobile apps assist with scheduling, treatment monitoring, and telemedicine, making it easier for clinics to manage patient care and expand their services digitally. By using AI, clinics can improve workflows, enhance patient outcomes, and reduce paperwork. Learn more about how we can assist at aidevmd.com. https://lnkd.in/gKpMKnjN #ClinicalTrials #AIinHealthcare #MedicalAI #HealthTech #DigitalHealth #PatientCareAI #AIResearch #MedicalInnovation #BioTech #AIforGood #HealthcareData #AIinMedicine #PharmaAI #ClinicalData #HealthAI #AIHealthSolutions #PrecisionMedicine #AIandHealth #ClinicalAnalytics #AIDiagnostics

In der Quantenoptik und Quanteninformatik findet das Mach-Zehnder-Interferometer in vielen Experimenten (und Gedankenexperimenten) Anwendung, so zum Beispiel in Delayed-Choice- und Quantenradierer-Experimenten, bei der Implementierung von Bell-Mesungen[5] und Quantengattern[6] oder im Elitzur-Vaidman Bombentest.

Chief Innovation Officer | AI & MedTech Leader Driving Global Healthcare Transformation | Inaugural Chair, FDA Digital Health Advisory Committee | Harvard Yale MGH trained Cardiologist

Improving patient-physician communication through shared decision-making is essential for enhancing outcomes and satisfaction in healthcare. A recent study focusing on patients undergoing Hallux Valgus correction found that perception of SDM was related to demographic and clinical factors. Patients with symptoms of depression and lower socioeconomic status reported lower levels of SDM. However, interestingly, postoperative outcomes were not directly influenced by SDM scores. This highlights the importance of addressing patient-specific factors in communication to improve overall satisfaction and quality of care. #PatientPhysicianCommunication #SharedDecisionMaking #HealthcareOutcomes #HalluxValgusStudy #patientexperience Laura Cooley, PhD Sage https://lnkd.in/easKhPzP