There are some wonderful toys in the lab that enable us to open up a whole new world in science. One of those is a rather pricey and an incredibly sensitive laser-based apparatus capable of counting and sorting cells, detecting biomarkers, and engineering proteins: the flow cytometer. By propelling cells through the path of the…

D Cialla-May · 2019 · 74 — Raman spectroscopy with its linear and nonlinear variants has established itself as a powerful analytical tool in almost all scientific fields.

These ultrasonic motor driven rotation stages provide high velocity to 720°/second and compact dimensions. They are equipped with optical, direct metrology ...

"However, deflecting light by diffraction grating allows much more precise control of the laser light compared to deflection in the Earth's atmosphere," says Schrödel.

Lightoptics

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He realized that a short laser pulse could be stretched in time—thereby making it less intense—by a diffraction grating that spreads the pulse into its component colors.

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Apoptosis, often called programmed cell death, is a carefully regulated process that is part of normal development and homeostasis. Apoptosis is morphologically and biochemically distinct from necrosis, which is conversely called accidental cell death. Dysregulation of apoptosis is implicated in disease states such as cancer, autoimmune disease and degenerative conditions. Apoptosis consists of an orderly…

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Telescopeoptics

Phosphorylation Equals Cell Signaling! How do cells communicate and respond to their environmental cues? This question has been on the hot list for scientists ever since the discovery of the cell. Cells use signaling cascades based on biochemical reactions to deliver or receive messages. How cool is that? The major secret of cell signaling was…

FlightOptics

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“It’s the best tasting diffraction grating you’ll ever see,” said David A. Weitz, a professor of physics and applied physics at Harvard, of the chocolate.

Lasers were once called “a solution looking for a problem.” The word—which is an acronym for Light Amplification by Stimulated Emission of Radiation—used to conjure up images of deadly weapons from Sci-Fi movies and TV series. However, their increasing use in everyday life, first in CD players and then in barcode scanners and pointers, have…

Lynnea has a PhD in Molecular Biology from University of California, Los Angeles, and is currently working as Medical Communications Senior Manager – Oncology at Amgen.

First Optic

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In my previous article I discussed steps you can implement to ensure that a sample is ready for cell sorting. But now it’s time to make sure the sort worked. Here are a few sorting checks and measures to ensure that all’s well that ends well. Post-sorting Checks and Measures Re-evaluate Your Catch Tubes Sorting…

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The electron microscope uses a beam of electrons and their wave-like characteristics to magnify an object's image, unlike the optical microscope that uses ...

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A Spot of History Most of the biomedical methods used started as a curiosity. Then the one-off gains a limited use, the technology then progresses until its use becomes widespread. Just think about the arch from the curious polished glass spheres, used by Antony Levnhook to look at animalcules, to modern microscopes. The same story…