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 2024-10-21 10:32:06

Quality-controlled organoids are manufactured at scale for high-throughput screening, leveraging proprietary bioreactor and bioprocess technology to produce reliable and predictive patient-derived organoids (PDOs).

For 40 years, we have partnered with scientists to help them achieve landmark discoveries. Our microplate readers and software are the industry’s most cited and have empowered life science researchers to advance protein and cell biology.

The addition of our colony picker platform expands the Center’s state-of-the-art methods and technologies to include automated workflows for synthetic biology, antibody discovery, and cell line development.

In the midst of an evolving drug discovery paradigm, researchers worldwide are transitioning their compound screens away from 2D cell cultures and animal models to more complex, human-relevant 3D systems like organoids. Experience our interactive infographic as it takes you deeper into why the industry is embracing this next generation of drug discovery and the innovations supporting scientists in their 3D biology journey.

The Organoid Innovation Center at Molecular Devices combines cutting-edge technologies with novel research methods to address key challenges of scaling complex 3D biological models.

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Fully-integrated, lab automation solution for molecular cloning, antibody discovery, and monoclonality. Our automated clone screening workflows integrate laboratory devices to increase your throughput and efficiency while reducing human interaction.

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Award-winning DispenCell™ Single-Cell Dispenser and the CloneSelect® Imager FL – our bundled solution offers unparalleled precision and efficiency in cell line development and monoclonality verification at day zero.

Ranging from automated digital microscopy to high-throughput confocal imaging systems with water immersion objectives, proprietary spinning disk technology, 7-channel laser light source, and machine-learning software analysis workflow.

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A leader in comprehensive GxP compliance solutions, we combine our SpectraMax® microplate readers, SoftMax® Pro GxP software, SpectraTest® Validation Plates and expert IQ/OQ/PM services to help laboratories operating under GMP and GLP regulations follow FDA or regional regulatory guidelines with confidence.

Moreover, it is very important to know that lenses with different focal lengthes can have the same magnification at different focusing distances. The table below shows various 1:1 life-size capable SLR lenses for Nikon SLR/DSLR bodies and their minimum focusing distances. It clearly showss that a lens with longer focal length has a larger minimum focusing distancce, even though all of the listed lenses have the same magnification. Consequently, the minimum focusing distance does not provide much information about the macro capability of a lens/camera. Lens Minimum Focusing Distance Nikon 60mm Micro 21.9cm Nikon 105mm Micro 31.4cm Nikon 200mm Micro 50cm Sigma 50mm Micro 18.8cm Sigma 105mm Micro 31.2cm Sigma 180mm Micro 46cm Tamron 90mm Micro 29cm Tamron 180mm Micro 47cm

From our PhD-level technical support staff to our expert-trained and certified field service engineers, we guide scientists through customized automation solutions that are uniquely designed to meet the specific needs of their assay, method, or protocol.

The distance between the subject and the front end of the lens is referred to as the working distance. A larger working distance will make lighting and composition easier. Another commonly seen term is focusing distance, which referrs to the distance when the lens is focused at a particular subject. Normally, the focusing distance is slightly larger than the working distance because working distance is measured from the front end of the lens. As we wll know that a shorter focal length yields a shorter working/focusing distance, hence a higher magnification. Virtually all consumer digital cameras use minimum focusing distance as the criterion for measuring macro capability. The following table shows some data. These cameras use different focal lengthes for macro shooting. Some of them use the wide angle end, while some use the middle focal range. Without knowing the focal length being used, the minimum focus distance tells little about the macro capability of the lens and camera. Camera Minimum Focusing Distance Canon PowerShot Pro1 3cm Fuji S2 Pro 1cm Nikon 4500 2cm Nikon 5400 1cm Nikon 5700/8700 3cm Olympus C-8080 5cm Pentax Optio 555 2cm Moreover, it is very important to know that lenses with different focal lengthes can have the same magnification at different focusing distances. The table below shows various 1:1 life-size capable SLR lenses for Nikon SLR/DSLR bodies and their minimum focusing distances. It clearly showss that a lens with longer focal length has a larger minimum focusing distancce, even though all of the listed lenses have the same magnification. Consequently, the minimum focusing distance does not provide much information about the macro capability of a lens/camera. Lens Minimum Focusing Distance Nikon 60mm Micro 21.9cm Nikon 105mm Micro 31.4cm Nikon 200mm Micro 50cm Sigma 50mm Micro 18.8cm Sigma 105mm Micro 31.2cm Sigma 180mm Micro 46cm Tamron 90mm Micro 29cm Tamron 180mm Micro 47cm

A critical step in the drug discovery process, drug screening and toxicity assessment uncover the effects of potentially life-saving compounds. Shifting to cell-based testing allows multiple chemicals to be tested rapidly and better represents human biology.

And, with the recent launch of CloneSelect® Imager FL with multi-channel fluorescence for day zero monoclonality verification and confirmation of CRISPR edits, provides a wide range of cell and gene therapy applications.

Lens Minimum Focusing Distance Nikon 60mm Micro 21.9cm Nikon 105mm Micro 31.4cm Nikon 200mm Micro 50cm Sigma 50mm Micro 18.8cm Sigma 105mm Micro 31.2cm Sigma 180mm Micro 46cm Tamron 90mm Micro 29cm Tamron 180mm Micro 47cm

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For every drug that makes it to the finish line, another nine don’t succeed. This alarming failure rate can be traced to reliance on 2D cell cultures that don’t closely mimic complex human biology, often leading to inaccurate predictions of a drug’s potential and extended drug development timelines.

The collaborative space brings customers and researchers into the lab to test automated workflows for organoid culturing and screening, with guidance from in-house scientists.

The QPix® 400 Microbial Colony Picker, ClonePix® 2 Mammalian Colony Picker, and CloneSelect® FL Imager increase throughput and consistency across cell line development, monoclonal antibody discovery, and synthetic biology workflows.

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Our cell line development customers accelerate time to market for life saving monoclonal antibodies (mAbs) and genomic medicine, as well as perform groundbreaking research in cell and gene therapies, genetic engineering, personalized and precision medicine, synthetic biology, RNA and DNA-based vaccines, and so much more – made possible by our innovative technology and rich expertise.

Improve your lab’s efficiency, get more data, and decrease time to discovery with an automated microplate reader and washer solution:

With our automated 3D cell culture and bioimaging screening solutions, we are helping reshape the future of drug discovery. Supported by our technology and organoid development protocols, researchers can now advance and scale screening methods for physiologically-relevant 3D models that more closely mimic patient disease states and human organs, leading to faster drug development and approval.

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Pioneering a new future of drug discovery rooted in 3D biology will empower researchers to personalize therapies, reduce a medicine’s time to market, and enhance quality of life for patients around the world.

An Al-driven cell culture innovation hub, the CellXpress.ai system automates processes, improves workflows, and makes assays more reliable and reproducible with machine learning-assisted monitoring, feeding, imaging and scheduling.

Explore our fully-integrated, automated workflow solutions for cell and biochemical assays. Our scalable ELISA Workcells provide walkaway time, increasing throughput, effectiveness and efficiency of the assay procedure, and reproducibility.

The drug discovery landscape is shifting, with more scientists centering cell line development, disease models, and high-throughput screening methods around physiologically-relevant 3D cell models.

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The reason for this is clear: Using cellular model systems in research that closely mimic patient disease states or human organs can bring life-saving therapeutics to market – faster.

Out-of-the-box integration of the enhanced BAB400 with the ImageXpress® Confocal HT.ai High-Content Imaging System and IN Carta® Image Analysis Software for an optimized end-to-end workflow solution for your 3D biology research.

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Leveraging proprietary bioprocess technology to produce reliable and predictive organoids at scale to innovating the cell culture system of the future, we believe in the revolutionary promise of 3D biology.

As we wll know that a shorter focal length yields a shorter working/focusing distance, hence a higher magnification. Virtually all consumer digital cameras use minimum focusing distance as the criterion for measuring macro capability. The following table shows some data. These cameras use different focal lengthes for macro shooting. Some of them use the wide angle end, while some use the middle focal range. Without knowing the focal length being used, the minimum focus distance tells little about the macro capability of the lens and camera. Camera Minimum Focusing Distance Canon PowerShot Pro1 3cm Fuji S2 Pro 1cm Nikon 4500 2cm Nikon 5400 1cm Nikon 5700/8700 3cm Olympus C-8080 5cm Pentax Optio 555 2cm Moreover, it is very important to know that lenses with different focal lengthes can have the same magnification at different focusing distances. The table below shows various 1:1 life-size capable SLR lenses for Nikon SLR/DSLR bodies and their minimum focusing distances. It clearly showss that a lens with longer focal length has a larger minimum focusing distancce, even though all of the listed lenses have the same magnification. Consequently, the minimum focusing distance does not provide much information about the macro capability of a lens/camera. Lens Minimum Focusing Distance Nikon 60mm Micro 21.9cm Nikon 105mm Micro 31.4cm Nikon 200mm Micro 50cm Sigma 50mm Micro 18.8cm Sigma 105mm Micro 31.2cm Sigma 180mm Micro 46cm Tamron 90mm Micro 29cm Tamron 180mm Micro 47cm

Camera Minimum Focusing Distance Canon PowerShot Pro1 3cm Fuji S2 Pro 1cm Nikon 4500 2cm Nikon 5400 1cm Nikon 5700/8700 3cm Olympus C-8080 5cm Pentax Optio 555 2cm Moreover, it is very important to know that lenses with different focal lengthes can have the same magnification at different focusing distances. The table below shows various 1:1 life-size capable SLR lenses for Nikon SLR/DSLR bodies and their minimum focusing distances. It clearly showss that a lens with longer focal length has a larger minimum focusing distancce, even though all of the listed lenses have the same magnification. Consequently, the minimum focusing distance does not provide much information about the macro capability of a lens/camera. Lens Minimum Focusing Distance Nikon 60mm Micro 21.9cm Nikon 105mm Micro 31.4cm Nikon 200mm Micro 50cm Sigma 50mm Micro 18.8cm Sigma 105mm Micro 31.2cm Sigma 180mm Micro 46cm Tamron 90mm Micro 29cm Tamron 180mm Micro 47cm