Diffuse lightin computer graphics

The thin films can form tiny microtubes with diameters that are less than a micrometer. This enables them to gently, but snugly, wrap around highly curved axons and dendrites.

“It is possible to very finely control the diameter of the rolling. You can stop if when you reach a particular dimension you want by tuning the light energy accordingly,” Sarkar explains.

The researchers also demonstrated how the devices can be combined with optoelectrical materials that can stimulate cells. Moreover, atomically thin materials can be patterned on top of the devices, which can still roll to form microtubes without breaking. This opens up opportunities for integrating sensors and circuits in the devices.

202288 — The clear aperture indicates the optical area meeting quality standards, with tolerances impacting performance and manufacturing complexity.

In addition, because they make such a tight connection with cells, one could use very little energy to stimulate subcellular regions. This could enable a researcher or clinician to modulate electrical activity of neurons for treating brain diseases.

The state-of-the-art full-colored handbook gives a comprehensive introduction to the principles and the practice of calculation, layout, and understanding ...

Diffuse lightbulb

Materials that exhibit light diffusion are often characterized by a lack of clarity or transparency. Instead of transmitting light in a focused and direct manner, these materials scatter the incident light, making the illumination more uniform and reducing the visibility of individual light sources. This scattering of light can create a softer and more even distribution of illumination, minimizing harsh shadows and glare.

Because these devices are wireless and free-floating, the researchers envision that thousands of tiny devices could someday be injected and then actuated noninvasively using light. Researchers would precisely control how the wearables gently wrap around cells, by manipulating the dose of light shined from outside the body, which would penetrate the tissue and actuate the devices.

A baking step ensures all solvents are evaporated and then they use etching to scrape away any material that remains between individual devices. Finally, they dissolve the sacrificial layer in water, leaving thousands of microscopic devices freely floating in the liquid.

Images for download on the MIT News office website are made available to non-commercial entities, press and the general public under a Creative Commons Attribution Non-Commercial No Derivatives license. You may not alter the images provided, other than to crop them to size. A credit line must be used when reproducing images; if one is not provided below, credit the images to "MIT."

They begin by depositing a drop of azobenzene onto a sacrificial layer composed of a water-soluble material. Then the researchers press a stamp onto the drop of polymer to mold thousands of tiny devices on top of the sacrificial layer. The stamping technique enables them to create complex structures, from rectangles to flower shapes.

Diffuse lightvs directlight

By enfolding axons that transmit electrical impulses between neurons and to other parts of the body, these wearables could help restore some neuronal degradation that occurs in diseases like multiple sclerosis. In the long run, the devices could be integrated with other materials to create tiny circuits that could measure and modulate individual cells.

Due to a material transformation, thin sheets of azobenzene will roll when exposed to light, enabling them to wrap around cells. Researchers can precisely control the direction and diameter of the rolling by varying the intensity and polarization of the light, as well as the shape of the devices.

The research was supported by the Swiss National Science Foundation and the U.S. National Institutes of Health Brain Initiative.

“This work is an exciting step toward new symbiotic neural interfaces acting at the level of the individual axons and synapses. When integrated with nanoscale 1- and 2D conductive nanomaterials, these light-responsive azobenzene sheets could become a versatile platform to sense and deliver different types of signals (i.e., electrical, optical, thermal, etc.) to neurons and other types of cells in a minimally or noninvasive manner. Although preliminary, the cytocompatibility data reported in this work is also very promising for future use in vivo,” says Flavia Vitale, associate professor of neurology, bioengineering, and physical medicine and rehabilitation at the University of Pennsylvania, who was not involved with this work.

Among the biggest challenges they faced was developing a scalable fabrication process that could be performed outside a clean room. They also iterated on the ideal thickness for the devices, since making them too thick causes cracking when they roll.

The researchers experimented with several fabrication techniques to find a process that was scalable and wouldn’t require the use of a semiconductor clean room.

Once they have a solution with free-floating devices, they wirelessly actuated the devices with light to induce the devices to roll. They found that free-floating structures can maintain their shapes for days after illumination stops.

The Lumen can be defined as the luminous flux emitted per unit solid angle from a uniform point source whose luminous intensity is 1 candela. (1 candela = 1 ...

Diffuse lightCeiling

Light diffusion refers to the process by which light is scattered or spread out in various directions as it interacts with a medium or material. Unlike direct transmission through a transparent medium, where light travels in a straight line, diffusion causes light to disperse in different directions due to interactions with the microscopic irregularities or variations in the material.

Wearable devices like smartwatches and fitness trackers interact with parts of our bodies to measure and learn from internal processes, such as our heart rate or sleep stages.

May design and test interfaces that facilitate the human-computer interaction and maximize the usability of digital devices, websites, and software with a focus ...

At the same time, axons and other cellular components are fragile, so any device that interfaces with them must be soft enough to make good contact without harming them.

Diffuse lightlamp

Cerchi un lavoro in un'azienda divertente e in crescita? Scopri le opportunità nella nostra sede centrale di Amsterdam o in altre strutture in Europa.

Sarkar is joined on the paper by lead author Marta J. I. Airaghi Leccardi, a former MIT postdoc who is now a Novartis Innovation Fellow; Benoît X. E. Desbiolles, an MIT postdoc; Anna Y. Haddad ’23, who was an MIT undergraduate researcher during the work; and MIT graduate students Baju C. Joy and Chen Song. The research appears today in Nature Communications Chemistry.

“It is exciting to demonstrate this symbiosis of an artificial device with a cell at an unprecedented resolution. We have shown that this technology is possible,” Sarkar says.

In addition to exploring these applications, the researchers want to try functionalizing the device surfaces with molecules that would enable them to target specific cell types or subcellular regions.

Brain cells have complex shapes, which makes it exceedingly difficult to create a bioelectronic implant that can tightly conform to neurons or neuronal processes. For instance, axons are slender, tail-like structures that attach to the cell body of neurons, and their length and curvature vary widely.

UV LED light LED is widely used in the disinfection, curing, painting and other fields, for example, ultraviolet disinfection, ...

In non-myelinating diseases like multiple sclerosis, neurons lose some insulating myelin sheets. There is no biological way of regenerating them. By acting as synthetic myelin, the wearables might help restore neuronal function in MS patients.

Diffused lighting interior design

Diffuse lightexample

Biglamp 114 min 280 W - max 1350 W Asymmetric Wallwasher, Elliptic Flood, Elliptic Spot, Flood, +4 3000 K - 4000 K - 5700 K

“To have intimate interfaces with these cells, the devices must be soft and able to conform to these complex structures. That is the challenge we solved in this work. We were the first to show that azobenzene could even wrap around living cells,” she says.

Overall, light diffusion is a phenomenon that plays a crucial role in achieving desirable lighting effects and visual comfort in various practical and artistic applications.

Now, MIT researchers have developed wearable devices that may be able to perform similar functions for individual cells inside the body.

After perfecting the use of light to control rolling, they tested the devices on rat neurons and found they could tightly wrap around even highly curved axons and dendrites without causing damage.

“The concept and platform technology we introduce here is like a founding stone that brings about immense possibilities for future research,” says Deblina Sarkar, the AT&T Career Development Assistant Professor in the MIT Media Lab and Center for Neurobiological Engineering, head of the Nano-Cybernetic Biotrek Lab, and the senior author of a paper on this technique.

Diffuse lightphotography

Because azobenzene is an insulator, one direct application is using the devices as synthetic myelin for axons that have been damaged. Myelin is an insulating layer that wraps axons and allows electrical impulses to travel efficiently between neurons.

Light diffusion is commonly employed in various applications, including photography, lighting design, display technologies, and architectural elements. Diffusion materials, such as frosted glass, diffuser panels, or certain types of plastics, are designed to scatter light and provide a more diffused and aesthetically pleasing illumination. In photography, diffusers are used to soften harsh lighting conditions, while in displays, diffusion layers can improve the visibility and readability of information.

Aims & Scope ... Optics and Lasers in Engineering aims at providing an international forum for the interchange of information on the development of optical ...

2024710 — Ventitrè medaglie di cui 7 d'oro, che valgono l'ottavo posto su 141 società provenienti da tutta Italia: è il risultato lusinghiero che la ...

These battery-free, subcellular-sized devices, made of a soft polymer, are designed to gently wrap around different parts of neurons, such as axons and dendrites, without damaging the cells, upon wireless actuation with light. By snugly wrapping neuronal processes, they could be used to measure or modulate a neuron’s electrical and metabolic activity at a subcellular level.

To overcome these challenges, the MIT researchers developed thin-film devices from a soft polymer called azobenzene, that don’t damage cells they enfold.