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AL amyloidosis happens when plasma cells making antibodies made of heavy and light protein chains make too many light protein chains. The light chains misfold and clump together, making amyloid fibrils that end up in your organs.

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There are several types of amyloidosis. Each type is named for the abnormal protein that causes the disease. In AL amyloidosis, A stands for amyloidosis and L stands for light chain, the protein that mutates and causes the disorder. Other common amyloidosis types are serum amyloid A protein (AA amyloidosis) and ATTR (transthyretin) amyloidosis.

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In AL amyloidosis, plasma cells making antibodies made of heavy and light protein chains make too many light protein chains. The light chains misfold and clump together, making amyloid fibrils that end up in your organs, where they can cause significant and life-threatening damage.

Providers may do several different tests to diagnose AL amyloidosis, but the most useful test is taking samples of the organ or organs affected by it. Providers may take the following biopsies:

Providers may use chemotherapy, immunotherapy or steroids to treat AL amyloidosis. Most people take one or two chemotherapy drugs plus steroid medication. The drugs work together to destroy the plasma cells that make light chain proteins.

Providers treat AL amyloidosis with medication and other treatments to ease your symptoms and address any organ damage. They also use treatments to slow down or stop the process causing your body to produce too many amyloids.

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AL amyloidosis is a plasma cell disorder. Plasma cells are part of your immune system. They make antibodies that fight infection. Every plasma cell divides repeatedly to make new cells or exact replicas of the specific plasma cell. Your body makes thousands of different plasma cell clones, each creating specific antibodies dedicated to fighting various infectious intruders. In plasma cell disorders, one plasma cell multiplies uncontrollably, making thousands of single antibodies.

Amyloidosis is a relatively rare disease that affects an estimated 9 to 14 in 1 million people in the United States and 5 to 12 in 1 million people worldwide. AL amyloidosis affects more males than females. It typically affects people aged 60 and older; 64 is the median age at diagnosis.

Healthcare providers are helping people to live longer with AL amyloidosis. For some people, AL amyloidosis is a long-term or chronic disease that providers can manage with medication. But it’s a very serious disease that may cause life-threatening medical conditions. AL amyloidosis is rare, which makes it difficult for providers to obtain enough information about the life expectancy for someone who has the condition. If you have AL amyloidosis, ask your healthcare provider about your prognosis or potential outcome after treatment. Your provider is your best resource for information on what you can expect.

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No, you can’t prevent AL amyloidosis or other forms of amyloidosis. AL amyloidosis happens when a single plasma cell makes a clone that begins to multiply uncontrollably.

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It’s important to remember medication can slow or stop AL amyloidosis from getting worse, but treatment doesn’t remove the fibrils already in your organs. After treatment starts, your own immune system can remove these abnormal proteins. Researchers are evaluating new monoclonal antibodies that may be able to remove fibrils.

AL amyloidosis (amyloid light chain or primary amyloidosis) is one type of amyloidosis. Amyloidosis (am-uh-loy-doh-sis) is a rare disorder that happens when plasma cells in your bone marrow change or mutate. These calls make abnormal proteins that become twisted clumps of misshaped proteins that gather on your organs and tissues. In AL amyloidosis, the proteins that mutate are light chain proteins. Light chain proteins are pieces of an infection-fighting antibody made by plasma cells in your bone marrow. AL amyloidosis typically affects your heart and/or your kidneys, but it may affect your stomach, intestine, nerves and skin. Healthcare providers may treat amyloidosis with chemotherapy and/or bone marrow or stem cell transplantation. If diagnosed and treated early on, AL amyloidosis may become a chronic disease. But left untreated, it leads to life-threatening conditions that may be fatal.

If you have AL amyloidosis, your healthcare provider will focus on treating your symptoms and slowing or stopping the progress of the disease. You may need ongoing medical treatments that have different side effects. One way you can take care of yourself is finding out about treatment side effects and ways to manage those side effects. Here are some other suggestions:

AL amyloidosis (amyloid light chain or primary amyloidosis) is a rare disease that happens when abnormal light chain proteins in your body gather on your organs and tissues. It's a serious illness that may become chronic or may cause life-threatening medical conditions. Healthcare providers are finding new ways to help people live longer with AL amyloidosis. If you have AL amyloidosis, ask your provider about clinical trials and research focused on new ways to treat it.

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AL amyloidosis (amyloid light chain or primary amyloidosis) is one type of the rare disorder amyloidosis. Amyloidosis happens when abnormal light chain proteins in your body gather on your heart, kidneys and other organs. Healthcare providers may treat amyloidosis with chemotherapy and/or bone marrow or stem cell transplantation.

AL amyloidosis may affect many parts of your body, from your head and neck to your limbs and organs. Many times, AL amyloidosis symptoms resemble other, less serious illnesses. They also develop slowly, which means you might not notice changes in your body right away.